Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597341097> ?p ?o ?g. }
- W2597341097 endingPage "1364" @default.
- W2597341097 startingPage "1354" @default.
- W2597341097 abstract "Several studies have shown that miR-320a induces apoptosis, inhibits cell proliferation, and affects cell cycle progression as a tumour suppressor in many cancers. However, the involvement of miR-320a in the invasion and metastasis of hepatocellular carcinoma (HCC) is still unknown.Endogenous miR-320a and high mobility group box 1 (HMGB1) expressions were assayed by real-time PCR. Luciferase activities were measured using a dual-luciferase reporter assay system. Western blots were used to determine the protein expressions of HMGB1, MMP2, and MMP9. Invasion and metastasis of tumour cells were, respectively, evaluated by the transwell invasion assay and the wound healing assay.The expression of miR-320a was significantly decreased in 24 of 32 (75%) HCC tissues and associated with the invasion and metastasis of HCC. Furthermore, we demonstrated that HMGB1 was a direct target of miR-320a and there was a significant negative correlation between miR-320a and HMGB1 expression in HCC. Ectopic expression or inhibition of miR-320a potently regulated the invasion and metastasis of HCC cells in HMGB1-dependent manner.Our results showed that miR-320a was involved in the invasion and metastasis by targeting HMGB1 and had an anti-metastasis effect in HCC." @default.
- W2597341097 created "2017-03-23" @default.
- W2597341097 creator A5003816728 @default.
- W2597341097 creator A5005259245 @default.
- W2597341097 creator A5017871162 @default.
- W2597341097 creator A5030436094 @default.
- W2597341097 creator A5039204587 @default.
- W2597341097 creator A5041320542 @default.
- W2597341097 creator A5046136378 @default.
- W2597341097 creator A5060921526 @default.
- W2597341097 creator A5070158905 @default.
- W2597341097 creator A5071747755 @default.
- W2597341097 creator A5073759462 @default.
- W2597341097 creator A5074966934 @default.
- W2597341097 creator A5080525975 @default.
- W2597341097 creator A5082391468 @default.
- W2597341097 creator A5089537405 @default.
- W2597341097 date "2017-04-11" @default.
- W2597341097 modified "2023-10-15" @default.
- W2597341097 title "miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma" @default.
- W2597341097 cites W1550667671 @default.
- W2597341097 cites W1757407923 @default.
- W2597341097 cites W1969305254 @default.
- W2597341097 cites W1981820702 @default.
- W2597341097 cites W1984596305 @default.
- W2597341097 cites W1985098845 @default.
- W2597341097 cites W1988626539 @default.
- W2597341097 cites W1989941644 @default.
- W2597341097 cites W2000881469 @default.
- W2597341097 cites W2005334224 @default.
- W2597341097 cites W2018786027 @default.
- W2597341097 cites W2026570544 @default.
- W2597341097 cites W2028718288 @default.
- W2597341097 cites W2040245755 @default.
- W2597341097 cites W2041250508 @default.
- W2597341097 cites W2048442498 @default.
- W2597341097 cites W2061943812 @default.
- W2597341097 cites W2068368007 @default.
- W2597341097 cites W2072079310 @default.
- W2597341097 cites W2072820594 @default.
- W2597341097 cites W2078564145 @default.
- W2597341097 cites W2080016731 @default.
- W2597341097 cites W2080476488 @default.
- W2597341097 cites W2086146050 @default.
- W2597341097 cites W2087438476 @default.
- W2597341097 cites W2098055602 @default.
- W2597341097 cites W2106396539 @default.
- W2597341097 cites W2112657305 @default.
- W2597341097 cites W2115293825 @default.
- W2597341097 cites W2171296186 @default.
- W2597341097 cites W2338698464 @default.
- W2597341097 cites W2492531936 @default.
- W2597341097 cites W2518332813 @default.
- W2597341097 doi "https://doi.org/10.1111/liv.13424" @default.
- W2597341097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28317284" @default.
- W2597341097 hasPublicationYear "2017" @default.
- W2597341097 type Work @default.
- W2597341097 sameAs 2597341097 @default.
- W2597341097 citedByCount "31" @default.
- W2597341097 countsByYear W25973410972017 @default.
- W2597341097 countsByYear W25973410972018 @default.
- W2597341097 countsByYear W25973410972019 @default.
- W2597341097 countsByYear W25973410972020 @default.
- W2597341097 countsByYear W25973410972021 @default.
- W2597341097 countsByYear W25973410972022 @default.
- W2597341097 countsByYear W25973410972023 @default.
- W2597341097 crossrefType "journal-article" @default.
- W2597341097 hasAuthorship W2597341097A5003816728 @default.
- W2597341097 hasAuthorship W2597341097A5005259245 @default.
- W2597341097 hasAuthorship W2597341097A5017871162 @default.
- W2597341097 hasAuthorship W2597341097A5030436094 @default.
- W2597341097 hasAuthorship W2597341097A5039204587 @default.
- W2597341097 hasAuthorship W2597341097A5041320542 @default.
- W2597341097 hasAuthorship W2597341097A5046136378 @default.
- W2597341097 hasAuthorship W2597341097A5060921526 @default.
- W2597341097 hasAuthorship W2597341097A5070158905 @default.
- W2597341097 hasAuthorship W2597341097A5071747755 @default.
- W2597341097 hasAuthorship W2597341097A5073759462 @default.
- W2597341097 hasAuthorship W2597341097A5074966934 @default.
- W2597341097 hasAuthorship W2597341097A5080525975 @default.
- W2597341097 hasAuthorship W2597341097A5082391468 @default.
- W2597341097 hasAuthorship W2597341097A5089537405 @default.
- W2597341097 hasConcept C104317684 @default.
- W2597341097 hasConcept C121608353 @default.
- W2597341097 hasConcept C126322002 @default.
- W2597341097 hasConcept C127561419 @default.
- W2597341097 hasConcept C137738243 @default.
- W2597341097 hasConcept C1491633281 @default.
- W2597341097 hasConcept C170493617 @default.
- W2597341097 hasConcept C190283241 @default.
- W2597341097 hasConcept C2775997469 @default.
- W2597341097 hasConcept C2778019345 @default.
- W2597341097 hasConcept C2779013556 @default.
- W2597341097 hasConcept C2780545709 @default.
- W2597341097 hasConcept C2780699576 @default.
- W2597341097 hasConcept C502942594 @default.
- W2597341097 hasConcept C54355233 @default.
- W2597341097 hasConcept C55493867 @default.