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• W2597371386 startingPage "198" @default.
• W2597371386 abstract "In recent years, while the research budget and development times increased for different phases of drug development, the number of clinically approved new medicines declined. In fact, many promising drug candidates failed to demonstrate their full therapeutic potential <em>in vivo</em>. Reasons for unfavorable outcome include some intrinsic properties of drugs, like biodegradation, solubility, and systemic toxicity, as well as the ways in which they are administered or the time elapsed until therapeutic efficiency is demonstrated. Therefore, to develop the full therapeutic potential of drug candidates <em>in vivo</em>, there is a need for advanced drug delivery systems that would carry the drug specifically to the target and release it there at desired concentrations. In addition, there is a requirement for non-invasive biomedical imaging technologies allowing for rapid and sensitive evaluations of drug performance <em>in vivo</em>. This review will present recent developments in bioengineered drug delivery systems, highlighting the biomedical imaging tools needed to evaluate the success of drug delivery strategies." @default.
• W2597371386 created "2017-03-23" @default.
• W2597371386 creator A5029127251 @default.
• W2597371386 creator A5072998448 @default.
• W2597371386 creator A5075026028 @default.
• W2597371386 creator A5084078696 @default.
• W2597371386 date "2017-01-01" @default.
• W2597371386 modified "2023-10-16" @default.
• W2597371386 title "Drug delivery from engineered organisms and nanocarriers as monitored by multimodal imaging technologies" @default.
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