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• W2597397443 abstract "Significance Initially discovered as a central repressor of the seedling photomorphogenesis in plants, and later characterized in animals, the E3 ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) has been shown to have conserved biochemical activities in eukaryotes. In this study, we show that to coordinately promote skotomorphogenesis, the COP1/ SUPPRESSOR of phyA-105 (SPA) complex represses the activity of the GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2) in a nonproteolytic manner to stabilize the key repressor of photomorphogenesis PHYTOCHROME INTERACTING FACTOR 3 (PIF3). The COP1/SPA-BIN2-PIF3 module represents an additional layer of COP1/SPA regulation in Arabidopsis and is essential for shaping the plants when grown in the dark." @default.
• W2597397443 created "2017-03-23" @default.
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• W2597397443 date "2017-03-14" @default.
• W2597397443 modified "2023-10-14" @default.
• W2597397443 title "Noncanonical role of <i>Arabidopsis</i> COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness" @default.
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• W2597397443 doi "https://doi.org/10.1073/pnas.1700850114" @default.
• W2597397443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5380025" @default.
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