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- W2597432471 abstract "Gold nanoparticles (AuNPs) have been increasingly integrated in biological systems, making it imperative to understand their interactions with cell membranes, the first barriers to be crossed to enter cells. Herein, liposomes composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) as a model membrane system were treated with citrate stabilized AuNPs from 5 to 30 nm at various concentrations. The fluorescence shifts of Laurdan probes reveal that AuNPs in general made liposomes more fluidic. The increased fluidity is expected to result in an increased surface area, and thus liposome shape changes from circular to less circular, which was further confirmed with fluorescence microscopy. The localized stress in lipids induced by electrostatically adsorbed AuNPs was hypothesized to cause the dominant long-range effect of fluidization of unbound lipid membranes. A secondary effect of the AuNP-induced lateral pressure is the membrane rupture or formation of pores, which was probed by AFM under fluid. We fo..." @default.
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- W2597432471 date "2016-10-16" @default.
- W2597432471 modified "2023-09-28" @default.
- W2597432471 title "Effects of Gold Nanoparticles on Lipid Packing and Membrane Pore Formation" @default.
- W2597432471 hasPublicationYear "2016" @default.
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