Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597442867> ?p ?o ?g. }
- W2597442867 endingPage "34110" @default.
- W2597442867 startingPage "34099" @default.
- W2597442867 abstract "Tec kinase, a prototypical member of the Tec tyrosine kinases family, was shown to mainly govern lymphocyte proliferation. In the present study, we investigated the role of Tec kinase in acute inflammatory response in lipopolysaccharide (LPS) challenge. First, we demonstrate that Tec kinase activity was observed in RAW264.7 macrophages exposed to LPS. Tec and phosphorylated Tec expression were upregulated in a dose- and time-dependent manner after LPS stimulation. LPS increased monocyte chemotactic protein (MCP)-1 secretion and intercellular adhesion molecule (ICAM)-1 expression, and increasing mRNA expression was consistently observed. LPS also induced IκBα phoshporylaytion and its degradation, increased NF-κB p65 phoshporylaytion and translocation to nuclei in RAW264.7 cells. Pretreatment with LFM-A13 decreased LPS-induced cytokines and chemokines production and mRNA levels, blocked NF-κB transactivation. These effects of LPS were also prevented by Tec-siRNA. Additionally, LFM-A13 or Tec-siRNA obviously inhibited LPS-induced TGFβ-activated kinase 1(TAK1) phosphorylation. Taken together, our results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 cells, at least mediated by activating TAK1/ NF-κB signal pathway." @default.
- W2597442867 created "2017-04-07" @default.
- W2597442867 creator A5001916762 @default.
- W2597442867 creator A5020206515 @default.
- W2597442867 creator A5024213189 @default.
- W2597442867 creator A5051757715 @default.
- W2597442867 creator A5055838753 @default.
- W2597442867 creator A5064720631 @default.
- W2597442867 creator A5086529957 @default.
- W2597442867 date "2017-03-15" @default.
- W2597442867 modified "2023-10-17" @default.
- W2597442867 title "Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway" @default.
- W2597442867 cites W1486041456 @default.
- W2597442867 cites W1528508275 @default.
- W2597442867 cites W1550579950 @default.
- W2597442867 cites W1573843383 @default.
- W2597442867 cites W1965721760 @default.
- W2597442867 cites W1966778344 @default.
- W2597442867 cites W1967095268 @default.
- W2597442867 cites W1987724650 @default.
- W2597442867 cites W1999768094 @default.
- W2597442867 cites W2000912815 @default.
- W2597442867 cites W2005311884 @default.
- W2597442867 cites W2008955645 @default.
- W2597442867 cites W2010559692 @default.
- W2597442867 cites W2010829192 @default.
- W2597442867 cites W2016445674 @default.
- W2597442867 cites W2026807204 @default.
- W2597442867 cites W2028464006 @default.
- W2597442867 cites W2041055293 @default.
- W2597442867 cites W2042115360 @default.
- W2597442867 cites W2055244310 @default.
- W2597442867 cites W2058699087 @default.
- W2597442867 cites W2061539575 @default.
- W2597442867 cites W2062417524 @default.
- W2597442867 cites W2067156757 @default.
- W2597442867 cites W2072362808 @default.
- W2597442867 cites W2073042614 @default.
- W2597442867 cites W2076247044 @default.
- W2597442867 cites W2077945837 @default.
- W2597442867 cites W2078923098 @default.
- W2597442867 cites W2083922442 @default.
- W2597442867 cites W2084780529 @default.
- W2597442867 cites W2122685956 @default.
- W2597442867 cites W2124376174 @default.
- W2597442867 cites W2136124244 @default.
- W2597442867 cites W2151469020 @default.
- W2597442867 cites W2151861846 @default.
- W2597442867 cites W2153071302 @default.
- W2597442867 cites W2153962607 @default.
- W2597442867 cites W2160167304 @default.
- W2597442867 cites W2160367702 @default.
- W2597442867 cites W2160550866 @default.
- W2597442867 cites W2168392561 @default.
- W2597442867 cites W2170108839 @default.
- W2597442867 cites W2227985055 @default.
- W2597442867 cites W2274633650 @default.
- W2597442867 cites W2275833676 @default.
- W2597442867 cites W2317550157 @default.
- W2597442867 cites W2326870169 @default.
- W2597442867 cites W2398879396 @default.
- W2597442867 doi "https://doi.org/10.18632/oncotarget.16212" @default.
- W2597442867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5470954" @default.
- W2597442867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28415764" @default.
- W2597442867 hasPublicationYear "2017" @default.
- W2597442867 type Work @default.
- W2597442867 sameAs 2597442867 @default.
- W2597442867 citedByCount "8" @default.
- W2597442867 countsByYear W25974428672018 @default.
- W2597442867 countsByYear W25974428672019 @default.
- W2597442867 countsByYear W25974428672020 @default.
- W2597442867 countsByYear W25974428672021 @default.
- W2597442867 countsByYear W25974428672023 @default.
- W2597442867 crossrefType "journal-article" @default.
- W2597442867 hasAuthorship W2597442867A5001916762 @default.
- W2597442867 hasAuthorship W2597442867A5020206515 @default.
- W2597442867 hasAuthorship W2597442867A5024213189 @default.
- W2597442867 hasAuthorship W2597442867A5051757715 @default.
- W2597442867 hasAuthorship W2597442867A5055838753 @default.
- W2597442867 hasAuthorship W2597442867A5064720631 @default.
- W2597442867 hasAuthorship W2597442867A5086529957 @default.
- W2597442867 hasBestOaLocation W25974428671 @default.
- W2597442867 hasConcept C116403925 @default.
- W2597442867 hasConcept C121332964 @default.
- W2597442867 hasConcept C1276947 @default.
- W2597442867 hasConcept C13373296 @default.
- W2597442867 hasConcept C153911025 @default.
- W2597442867 hasConcept C176379880 @default.
- W2597442867 hasConcept C184235292 @default.
- W2597442867 hasConcept C203014093 @default.
- W2597442867 hasConcept C2776914184 @default.
- W2597442867 hasConcept C2777730290 @default.
- W2597442867 hasConcept C2778754761 @default.
- W2597442867 hasConcept C2781184567 @default.
- W2597442867 hasConcept C71924100 @default.
- W2597442867 hasConcept C86803240 @default.
- W2597442867 hasConcept C8891405 @default.
- W2597442867 hasConcept C95444343 @default.