FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597451837> ?p ?o ?g. }

• W2597451837 endingPage "S148" @default.
• W2597451837 startingPage "S148" @default.
• W2597451837 abstract "Previous studies have shown a correlation between apparent diffusion co-efficient (ADC) values derived from diffusion weighted (DW) MRI and histopathological grade in pancreatic adenocarcinoma (PAC). Higher doses may need to be delivered to these poorly differentiated regions to improve local control and survival in a sub group of PAC patients. The purpose of this study was to investigate the feasibility of planning dose-escalation to ADC-defined GTVs using intensity modulated radiation therapy (IMRT). A total of 6 PAC patients who had DW-MRI T2 and multiphase dynamic contrast data acquired on a 3T MRI scanner during radiation therapy simulation were used for this planning study. The gross tumor volume (GTV) for each patient was manually delineated based on the ADC maps. The GTV volumes were transferred to fused T2 images for treatment planning purposes. A MR-based plan was developed using relative electron densities (rED) derived from international Commission on Radiation Units and Measurements (ICRU) report 46. Non-specified tissue (NST) rED was set to 1.022 and the mean rED of the PTV on CT was used for each patient. A research planning system employing Monte Carlo dose calculations was used to generate MR and CT-based IMRT plans. Common clinical dose-volume (DV) constraints were used in plan optimization. Plans were generated by maximizing the dose to ADC-defined GTV without violating the DV constraints. A series of DV parameters were used: the maximum and mean dose (Dmax and Dmean, respectively), dose covering 95% of the volume (D95) for PTV and the volume receiving >45 Gy (V45) and V53 for organs-at-risk (OAR). The MR-based plans were compared to the CT-based plans with respect to the previously mentioned DV parameters (DVPs). The level of dose-escalation to the ADC-defined GTV depends on the location, size, and shape of the GTV. The dose to GTV could be escalated to 56 Gy in 2 cases and 60 Gy in 1 case without violating the conventional OAR DV constraints. The 60 Gy could be escalated to 67 Gy based on the OAR constraints determined from consolidated isoeffective data. The percentage point (V45) and maximum relative (other DVPs) differences in various DV parameters between the CT and MR-based escalated dose distributions are tabulated in the Table. The safe dose escalation to the ADC-defined GTV in radiation therapy for pancreatic cancer depends on the location, size, and shape of the GTV. It is dosimetrically possible to safely escalate GTV dose to higher than 70 Gy in 1.8–2 Gy fractions for selective cases with the GTV not too big and too close to the surrounding normal tissue structures.Oral Scientific Abstracts 337; Table 1Pancreas PlansDmaxD95%DmaxV45V53PTV(56/60 Gy)-4.6%-3.0%PTV50.4 Gy1.8%-2.4%Duodenum-7.1%-33%-52.1%Stomach-1.9%8.4%-68.5%ADC GTV_escalated62.1 ± 2.2 Gy57.3 ± 2.3 GyADC_GTV_50.4 Gy55.1 ± 1.7 Gy51.6 ± 1.1 GyPTV677059 cGy6729 cGyDuodenum_PTV672.6%-15.9%-47.1% Open table in a new tab" @default.
• W2597451837 created "2017-04-07" @default.
• W2597451837 creator A5010816117 @default.
• W2597451837 creator A5013466201 @default.
• W2597451837 creator A5019557155 @default.
• W2597451837 creator A5064770980 @default.
• W2597451837 creator A5066889492 @default.
• W2597451837 creator A5067310306 @default.
• W2597451837 date "2015-11-01" @default.
• W2597451837 modified "2023-10-05" @default.
• W2597451837 title "Dosimetric Feasibility of Dose Painting Using ADC Map in MR Based Radiation Therapy for Pancreatic Cancer" @default.
• W2597451837 doi "https://doi.org/10.1016/j.ijrobp.2015.07.351" @default.
• W2597451837 hasPublicationYear "2015" @default.
• W2597451837 type Work @default.
• W2597451837 sameAs 2597451837 @default.
• W2597451837 citedByCount "0" @default.
• W2597451837 crossrefType "journal-article" @default.
• W2597451837 hasAuthorship W2597451837A5010816117 @default.
• W2597451837 hasAuthorship W2597451837A5013466201 @default.
• W2597451837 hasAuthorship W2597451837A5019557155 @default.
• W2597451837 hasAuthorship W2597451837A5064770980 @default.
• W2597451837 hasAuthorship W2597451837A5066889492 @default.
• W2597451837 hasAuthorship W2597451837A5067310306 @default.
• W2597451837 hasBestOaLocation W25974518371 @default.
• W2597451837 hasConcept C121608353 @default.
• W2597451837 hasConcept C126322002 @default.
• W2597451837 hasConcept C126838900 @default.
• W2597451837 hasConcept C201645570 @default.
• W2597451837 hasConcept C2780210213 @default.
• W2597451837 hasConcept C2989005 @default.
• W2597451837 hasConcept C509974204 @default.
• W2597451837 hasConcept C71924100 @default.
• W2597451837 hasConceptScore W2597451837C121608353 @default.
• W2597451837 hasConceptScore W2597451837C126322002 @default.
• W2597451837 hasConceptScore W2597451837C126838900 @default.
• W2597451837 hasConceptScore W2597451837C201645570 @default.
• W2597451837 hasConceptScore W2597451837C2780210213 @default.
• W2597451837 hasConceptScore W2597451837C2989005 @default.
• W2597451837 hasConceptScore W2597451837C509974204 @default.
• W2597451837 hasConceptScore W2597451837C71924100 @default.
• W2597451837 hasIssue "3" @default.
• W2597451837 hasLocation W25974518371 @default.
• W2597451837 hasOpenAccess W2597451837 @default.
• W2597451837 hasPrimaryLocation W25974518371 @default.
• W2597451837 hasRelatedWork W2057960324 @default.
• W2597451837 hasRelatedWork W2363834598 @default.
• W2597451837 hasRelatedWork W2410379488 @default.
• W2597451837 hasRelatedWork W2800720255 @default.
• W2597451837 hasRelatedWork W2901599149 @default.
• W2597451837 hasRelatedWork W2980781247 @default.
• W2597451837 hasRelatedWork W3153034825 @default.
• W2597451837 hasRelatedWork W4237240905 @default.
• W2597451837 hasRelatedWork W4243045879 @default.
• W2597451837 hasRelatedWork W935391112 @default.
• W2597451837 hasVolume "93" @default.
• W2597451837 isParatext "false" @default.
• W2597451837 isRetracted "false" @default.
• W2597451837 magId "2597451837" @default.
• W2597451837 workType "article" @default.