FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597471487> ?p ?o ?g. }

• W2597471487 endingPage "592" @default.
• W2597471487 startingPage "579" @default.
• W2597471487 abstract "Introduction: Alzheimer disease (AD) is the most common form of dementia and its incidence is increasing at an alarming rate all over the world. The pathophysiology of AD is characterized by chronic, progressive neurodegeneration which involves early synaptotoxicity. One of the most obvious pathological feature of AD is the accumulation of amyloid-β (Aβ) in the brain. Since current treatment options only provide symptomatic help and Aβ is thought to underlie early synaptic pathology, Aβ reduction or modulation in the brain may be a promising therapeutic strategy in preventing and /or reversing AD-related dysfunction.Areas covered: This paper outlines and evaluates the current landscape of preclinical and clinical studies focusing on modulating Aβ pathophysiology. Data and analysis for this review were procured from PubMed, clinicaltrials.gov and Alzforum.Expert opinion: According to current knowledge, reducing Aβ production offers numerous treatment options. However, targeting the initial steps by pharmacological interference with secretases is challenging due to the emergence of various side effects. The most promising approach seems to be the prevention of early Aβ oligomerization. Combination approaches targeting both Aβ and tau would seem to be another promising strategy that could have beneficial effects through the course of the disease." @default.
• W2597471487 created "2017-04-07" @default.
• W2597471487 creator A5057517491 @default.
• W2597471487 creator A5071702581 @default.
• W2597471487 date "2017-04-24" @default.
• W2597471487 modified "2023-10-14" @default.
• W2597471487 title "Preclinical to phase II amyloid beta (A_β) peptide modulators under investigation for Alzheimer’s disease" @default.
• W2597471487 cites W139300322 @default.
• W2597471487 cites W1513568277 @default.
• W2597471487 cites W1553011341 @default.
• W2597471487 cites W1560487523 @default.
• W2597471487 cites W1587774683 @default.
• W2597471487 cites W1657062239 @default.
• W2597471487 cites W1664338907 @default.
• W2597471487 cites W1664694034 @default.
• W2597471487 cites W186149320 @default.
• W2597471487 cites W1862461292 @default.
• W2597471487 cites W1885651420 @default.
• W2597471487 cites W1888183027 @default.
• W2597471487 cites W1964587084 @default.
• W2597471487 cites W1964673167 @default.
• W2597471487 cites W1972567838 @default.
• W2597471487 cites W1975492746 @default.
• W2597471487 cites W1976602187 @default.
• W2597471487 cites W1976923044 @default.
• W2597471487 cites W1978999542 @default.
• W2597471487 cites W1980825524 @default.
• W2597471487 cites W1981458288 @default.
• W2597471487 cites W1985110467 @default.
• W2597471487 cites W1985570437 @default.
• W2597471487 cites W1990350348 @default.
• W2597471487 cites W1990632702 @default.
• W2597471487 cites W1990774375 @default.
• W2597471487 cites W1991988242 @default.
• W2597471487 cites W1993465897 @default.
• W2597471487 cites W1993759415 @default.
• W2597471487 cites W1997146656 @default.
• W2597471487 cites W1998933601 @default.
• W2597471487 cites W1999017783 @default.
• W2597471487 cites W2001330707 @default.
• W2597471487 cites W2007495000 @default.
• W2597471487 cites W2010233543 @default.
• W2597471487 cites W2011347889 @default.
• W2597471487 cites W2012139588 @default.
• W2597471487 cites W2014109882 @default.
• W2597471487 cites W2023274935 @default.
• W2597471487 cites W2025561374 @default.
• W2597471487 cites W2026422955 @default.
• W2597471487 cites W2028457208 @default.
• W2597471487 cites W2032061707 @default.
• W2597471487 cites W2032602280 @default.
• W2597471487 cites W2033354781 @default.
• W2597471487 cites W2038342320 @default.
• W2597471487 cites W2040721710 @default.
• W2597471487 cites W2041425500 @default.
• W2597471487 cites W2041573170 @default.
• W2597471487 cites W2045855955 @default.
• W2597471487 cites W2046484785 @default.
• W2597471487 cites W2048224964 @default.
• W2597471487 cites W2051764561 @default.
• W2597471487 cites W2052742260 @default.
• W2597471487 cites W2053665966 @default.
• W2597471487 cites W2054685711 @default.
• W2597471487 cites W2055659156 @default.
• W2597471487 cites W2056092494 @default.
• W2597471487 cites W2056414888 @default.
• W2597471487 cites W2058581619 @default.
• W2597471487 cites W2065706231 @default.
• W2597471487 cites W2070071706 @default.
• W2597471487 cites W2070880671 @default.
• W2597471487 cites W2072578105 @default.
• W2597471487 cites W2072625029 @default.
• W2597471487 cites W2072720067 @default.
• W2597471487 cites W2074238436 @default.
• W2597471487 cites W2075481535 @default.
• W2597471487 cites W2075967168 @default.
• W2597471487 cites W2076184221 @default.
• W2597471487 cites W2076305899 @default.
• W2597471487 cites W2076654506 @default.
• W2597471487 cites W2078459727 @default.
• W2597471487 cites W2078646014 @default.
• W2597471487 cites W2078670226 @default.
• W2597471487 cites W2078917784 @default.
• W2597471487 cites W2080225612 @default.
• W2597471487 cites W2081735359 @default.
• W2597471487 cites W2082856520 @default.
• W2597471487 cites W2084121214 @default.
• W2597471487 cites W2084280842 @default.
• W2597471487 cites W2087581147 @default.
• W2597471487 cites W2088897156 @default.
• W2597471487 cites W2089890181 @default.
• W2597471487 cites W2090349395 @default.
• W2597471487 cites W2095303207 @default.
• W2597471487 cites W2096410114 @default.
• W2597471487 cites W2098035383 @default.
• W2597471487 cites W2098374631 @default.
• W2597471487 cites W2098409932 @default.
• W2597471487 cites W2099271519 @default.

• next