Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597474494> ?p ?o ?g. }
- W2597474494 endingPage "29079" @default.
- W2597474494 startingPage "29067" @default.
- W2597474494 abstract "The bispecific antibody is a novel antibody, which can target two different antigens and mediate specific killing effects by selectively redirecting effector cells to the target cells. Here, we designed and synthesized a bispecific antibody (BsAb) that can bind cellular-mesenchymal to epithelial transition factor (c-MET, overexpressed in several human solid tumor), and programmed death-1 (PD-1, involved in cancer cell immune evasion) with high affinity and specificity. We found that BsAb can induce the degradation of c-MET protein in cancer cells, including MKN45, a gastric cancer cell line, and A549, a lung cancer cell line. BsAb inhibited hepatocyte growth factor (HGF)-mediated proliferation, migration, and antiapoptosis, and downregulated HGF-stimulated phosphorylation of c-MET, protein kinase B (AKT), and extracellular signal-regulated kinase (ERK1/2). BsAb can also rescue T cell activation. Furthermore, xenograft analysis revealed that BsAb markedly inhibits the growth of subcutaneously implanted tumors and chronic inflammation. On the basis of these results, we have identified a potential bispecific drug, which can effectively target c-MET and PD-1 for the treatment of human solid cancers." @default.
- W2597474494 created "2017-04-07" @default.
- W2597474494 creator A5020353950 @default.
- W2597474494 creator A5023498248 @default.
- W2597474494 creator A5033671938 @default.
- W2597474494 creator A5039231803 @default.
- W2597474494 creator A5059912107 @default.
- W2597474494 creator A5069923117 @default.
- W2597474494 creator A5088546128 @default.
- W2597474494 date "2017-03-14" @default.
- W2597474494 modified "2023-10-15" @default.
- W2597474494 title "A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer" @default.
- W2597474494 cites W1489143753 @default.
- W2597474494 cites W1499120372 @default.
- W2597474494 cites W1518945847 @default.
- W2597474494 cites W1837507354 @default.
- W2597474494 cites W1905566048 @default.
- W2597474494 cites W1940241680 @default.
- W2597474494 cites W1970127044 @default.
- W2597474494 cites W1973248233 @default.
- W2597474494 cites W1978368856 @default.
- W2597474494 cites W1979810161 @default.
- W2597474494 cites W1982487075 @default.
- W2597474494 cites W1982488143 @default.
- W2597474494 cites W1985562847 @default.
- W2597474494 cites W1986159749 @default.
- W2597474494 cites W1992449776 @default.
- W2597474494 cites W2007640949 @default.
- W2597474494 cites W2012871610 @default.
- W2597474494 cites W2018495916 @default.
- W2597474494 cites W2021588881 @default.
- W2597474494 cites W2027216690 @default.
- W2597474494 cites W2032942559 @default.
- W2597474494 cites W2041551369 @default.
- W2597474494 cites W2064358249 @default.
- W2597474494 cites W2066671159 @default.
- W2597474494 cites W2073597573 @default.
- W2597474494 cites W2074242691 @default.
- W2597474494 cites W2079562074 @default.
- W2597474494 cites W2081119236 @default.
- W2597474494 cites W2090498592 @default.
- W2597474494 cites W2092274867 @default.
- W2597474494 cites W2098414192 @default.
- W2597474494 cites W2101653483 @default.
- W2597474494 cites W2104149001 @default.
- W2597474494 cites W2112417311 @default.
- W2597474494 cites W2115918781 @default.
- W2597474494 cites W2119335520 @default.
- W2597474494 cites W2120460652 @default.
- W2597474494 cites W2124427232 @default.
- W2597474494 cites W2128758225 @default.
- W2597474494 cites W2129806226 @default.
- W2597474494 cites W2136390065 @default.
- W2597474494 cites W2143163879 @default.
- W2597474494 cites W2155464214 @default.
- W2597474494 cites W2156353875 @default.
- W2597474494 cites W2156383220 @default.
- W2597474494 cites W2160834915 @default.
- W2597474494 cites W2162411203 @default.
- W2597474494 cites W2164042520 @default.
- W2597474494 cites W2166662937 @default.
- W2597474494 cites W2168114478 @default.
- W2597474494 cites W2211884070 @default.
- W2597474494 cites W2266844207 @default.
- W2597474494 cites W2289666033 @default.
- W2597474494 cites W2290610287 @default.
- W2597474494 cites W2328212946 @default.
- W2597474494 cites W2403476749 @default.
- W2597474494 cites W2417995166 @default.
- W2597474494 cites W2560367415 @default.
- W2597474494 cites W2572174216 @default.
- W2597474494 cites W4230744147 @default.
- W2597474494 cites W4238423864 @default.
- W2597474494 cites W4239448198 @default.
- W2597474494 doi "https://doi.org/10.18632/oncotarget.16173" @default.
- W2597474494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5438713" @default.
- W2597474494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28404966" @default.
- W2597474494 hasPublicationYear "2017" @default.
- W2597474494 type Work @default.
- W2597474494 sameAs 2597474494 @default.
- W2597474494 citedByCount "28" @default.
- W2597474494 countsByYear W25974744942018 @default.
- W2597474494 countsByYear W25974744942020 @default.
- W2597474494 countsByYear W25974744942021 @default.
- W2597474494 countsByYear W25974744942022 @default.
- W2597474494 countsByYear W25974744942023 @default.
- W2597474494 crossrefType "journal-article" @default.
- W2597474494 hasAuthorship W2597474494A5020353950 @default.
- W2597474494 hasAuthorship W2597474494A5023498248 @default.
- W2597474494 hasAuthorship W2597474494A5033671938 @default.
- W2597474494 hasAuthorship W2597474494A5039231803 @default.
- W2597474494 hasAuthorship W2597474494A5059912107 @default.
- W2597474494 hasAuthorship W2597474494A5069923117 @default.
- W2597474494 hasAuthorship W2597474494A5088546128 @default.
- W2597474494 hasBestOaLocation W25974744941 @default.
- W2597474494 hasConcept C121608353 @default.
- W2597474494 hasConcept C126322002 @default.
- W2597474494 hasConcept C159654299 @default.