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- W2597523916 abstract "The members of the PhosphoInositide-3 Kinase (PI3K) protein family are well-known regulators of proliferative signals. By the generation of lipid second messengers, they mediate the activation of AKT/PKB (AKT) and mammalian Target Of Rapamycin (mTOR) pathways. Although mutations in the PI3K/AKT/mTOR pathway are highly characterized in cancer, recent evidence indicates that alterations in the proliferative signals are major drivers of other diseases such as overgrowth disorders and polycystic kidney disease. In this review, we briefly summarize the role of the PI3K/AKT/mTOR pathway in cell proliferation by comparing the effect of alterations in PI3K enzymes in different tissues. In particular, we discuss the most recent findings on how the same pathway may lead to different biological effects, due to the convergence and cooperation of different signaling cascades." @default.
- W2597523916 created "2017-04-07" @default.
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- W2597523916 creator A5075168526 @default.
- W2597523916 creator A5085452501 @default.
- W2597523916 date "2017-03-29" @default.
- W2597523916 modified "2023-09-25" @default.
- W2597523916 title "PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts" @default.
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- W2597523916 doi "https://doi.org/10.3390/cancers9040030" @default.
- W2597523916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5406705" @default.
- W2597523916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28353628" @default.
- W2597523916 hasPublicationYear "2017" @default.
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