Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597700712> ?p ?o ?g. }
- W2597700712 abstract "Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope. Here, we report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. Within the transport-activated state, the channel remains open even though the pump cycles through three distinct conformations. Collectively, our data provide a dynamic mechanism for the assembly and operation of the AcrAB-TolC pump." @default.
- W2597700712 created "2017-04-07" @default.
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- W2597700712 date "2017-03-29" @default.
- W2597700712 modified "2023-10-16" @default.
- W2597700712 title "An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump" @default.
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- W2597700712 doi "https://doi.org/10.7554/elife.24905" @default.
- W2597700712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5404916" @default.
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