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- W2597734160 abstract "Propacetamol, IV acetaminophen, is the most commonly used analgesia for moderate to severe postoperative pain, and nefopam is a centrally-acting analgesic drug. The purpose of this study is to find out the efficacy of using propacetamol with nefofam compared to the use of propacetamol or nefopam alone for acute and chronic pain after thyroid surgery. Eighty-four patients were randomly allocated into the three groups: propacetamol group, nefopam group, and combined (propacetamol with nefopam) group. They received the analgesics 30 minutes before the end of the surgery and then every 6 hours during the postoperative 24 hours. If the pain was persistent, tramadol 50 mg was administered as a rescue medicine. The intensity of the pain on the wound site and posterior neck area was recorded using a numeric rating scale (0 to 10) at the admission of post-anesthetic care unit (PACU) on the post-operative day 1 and three months after the surgery. The results showed that the pain scores on the wound site were significantly lower for the combined (propacetamol with nefopam) group compared to the propacetamol or nefopam alone groups at the admission of PACU [median (range): 3 (0-8), 5 (3-8), and 4 (0-9), respectively, p-value <0.05, although no significant differences were found with the pain scores among the three groups at the post-operative day 1, and three months after the surgery. In addition, no significant differences were found for the incidences of neuropathic pain, rescue pain medication, and adverse effects such as sedation, nausea, vomiting, dry mouth, tachycardia, sweating, and dizziness. In conclusion, the combination of propacetamol and nefopam produced a more effective analgesic effect rather than using single medicine immediately after the surgery although the differences were dismissed at post-operative day 1 and three months after the surgery." @default.
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- W2597734160 date "2017-04-01" @default.
- W2597734160 modified "2023-09-27" @default.
- W2597734160 title "(389) The combination effect of propacetamol with nefopam for postoperative pain after thyroidectomy" @default.
- W2597734160 doi "https://doi.org/10.1016/j.jpain.2017.02.363" @default.
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