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- W2597753670 abstract "Background: Rare mutations in the proopiomelanocortin gene(POMC) have been previously reported to cause early-onsetchildhood obesity and the POMC locus (2p21) has been linked toleptin levels and body mass index (BMI). Objectives: In thisstudy, we investigated possible associations of C1032Gpolymorphism (dbSNP ID rs1009388) within the first intron ofPOMC gene with chronic heart failure. Methods: 247 patients ofcaucasian origin with chronic heart failure (functional classesNYHA II-IV, ejection fraction (EF) < 40%) have beeninvestigated in comparison to 198 healthy volunteers of similarage and gender distribution. Results: No differences ingenotype distributions or allelic frequencies of the examinedC1032G POMC polymorphism have been observed when comparing thechronic heart failure patients and the control subjects. Therewas no association between any of followed patientscharacteristics (age, gender, diabetes I, II,hyperlipoproteinemia, NYHA class, EF, CRP plasma levels, reninplasma levels, aldosterone plasma levels, big endothelin andendothelin-1 plasma levels, fibrinogene plasma levels andglucose plasma levels) and genotypes of the polymorphism.Conclusions: Based on our results, C1032G polymorphism withinthe first intron of POMC gene is not associated with chronicheart failure, neither in a case-control study nor whenassociating specific variants of the examined polymorphism withpatients characteristics." @default.
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- W2597753670 date "2007-01-01" @default.
- W2597753670 modified "2023-10-04" @default.
- W2597753670 title "Proopiomelanocortin gene variability and chronic heart failure:no association so far" @default.
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