Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597757902> ?p ?o ?g. }
- W2597757902 endingPage "2075" @default.
- W2597757902 startingPage "2069" @default.
- W2597757902 abstract "The Middle East respiratory syndrome coronavirus (MERS-CoV), is an emerging pathogen that continues to cause outbreaks in the Arabian peninsula and in travelers from this region, raising the concern that a global pandemic could occur. Here, we show that a DNA vaccine encoding the first 725 amino acids (S1) of MERS-CoV spike (S) protein induces antigen-specific humoral and cellular immune responses in mice. With three immunizations, high titers of neutralizing antibodies (up to 1: 104) were generated without adjuvant. DNA vaccination with the MERS-CoV S1 gene markedly increased the frequencies of antigen-specific CD4+ and CD8+ T cells secreting IFN-γ and other cytokines. Both pcDNA3.1-S1 DNA vaccine immunization and passive transfer of immune serum from pcDNA3.1-S1 vaccinated mice protected Ad5-hDPP4-transduced mice from MERS-CoV challenge. These results demonstrate that a DNA vaccine encoding MERS-CoV S1 protein induces strong protective immune responses against MERS-CoV infection." @default.
- W2597757902 created "2017-04-07" @default.
- W2597757902 creator A5006028447 @default.
- W2597757902 creator A5007689920 @default.
- W2597757902 creator A5007803202 @default.
- W2597757902 creator A5017084251 @default.
- W2597757902 creator A5017985995 @default.
- W2597757902 creator A5020084371 @default.
- W2597757902 creator A5023693252 @default.
- W2597757902 creator A5034517280 @default.
- W2597757902 creator A5051474892 @default.
- W2597757902 creator A5058518849 @default.
- W2597757902 date "2017-04-01" @default.
- W2597757902 modified "2023-10-17" @default.
- W2597757902 title "DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice" @default.
- W2597757902 cites W105687232 @default.
- W2597757902 cites W1156591228 @default.
- W2597757902 cites W1707611338 @default.
- W2597757902 cites W1860284492 @default.
- W2597757902 cites W1872165394 @default.
- W2597757902 cites W1947023024 @default.
- W2597757902 cites W1972591948 @default.
- W2597757902 cites W1984378774 @default.
- W2597757902 cites W1998952429 @default.
- W2597757902 cites W2011500306 @default.
- W2597757902 cites W2012505332 @default.
- W2597757902 cites W2030896204 @default.
- W2597757902 cites W2031436792 @default.
- W2597757902 cites W2032377144 @default.
- W2597757902 cites W2069902539 @default.
- W2597757902 cites W2076440471 @default.
- W2597757902 cites W2078121682 @default.
- W2597757902 cites W2083547697 @default.
- W2597757902 cites W2084340904 @default.
- W2597757902 cites W2084953052 @default.
- W2597757902 cites W2092685402 @default.
- W2597757902 cites W2096084302 @default.
- W2597757902 cites W2098870916 @default.
- W2597757902 cites W2103807321 @default.
- W2597757902 cites W2107053896 @default.
- W2597757902 cites W2112147913 @default.
- W2597757902 cites W2119111857 @default.
- W2597757902 cites W2127106192 @default.
- W2597757902 cites W2138436490 @default.
- W2597757902 cites W2159465958 @default.
- W2597757902 cites W2166867592 @default.
- W2597757902 cites W2216419812 @default.
- W2597757902 cites W2223502995 @default.
- W2597757902 cites W2261569298 @default.
- W2597757902 cites W2270879391 @default.
- W2597757902 cites W2285594236 @default.
- W2597757902 cites W2286137332 @default.
- W2597757902 cites W2298205133 @default.
- W2597757902 cites W2314158862 @default.
- W2597757902 cites W2403476527 @default.
- W2597757902 doi "https://doi.org/10.1016/j.vaccine.2017.02.063" @default.
- W2597757902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5411280" @default.
- W2597757902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28314561" @default.
- W2597757902 hasPublicationYear "2017" @default.
- W2597757902 type Work @default.
- W2597757902 sameAs 2597757902 @default.
- W2597757902 citedByCount "49" @default.
- W2597757902 countsByYear W25977579022017 @default.
- W2597757902 countsByYear W25977579022018 @default.
- W2597757902 countsByYear W25977579022019 @default.
- W2597757902 countsByYear W25977579022020 @default.
- W2597757902 countsByYear W25977579022021 @default.
- W2597757902 countsByYear W25977579022022 @default.
- W2597757902 countsByYear W25977579022023 @default.
- W2597757902 crossrefType "journal-article" @default.
- W2597757902 hasAuthorship W2597757902A5006028447 @default.
- W2597757902 hasAuthorship W2597757902A5007689920 @default.
- W2597757902 hasAuthorship W2597757902A5007803202 @default.
- W2597757902 hasAuthorship W2597757902A5017084251 @default.
- W2597757902 hasAuthorship W2597757902A5017985995 @default.
- W2597757902 hasAuthorship W2597757902A5020084371 @default.
- W2597757902 hasAuthorship W2597757902A5023693252 @default.
- W2597757902 hasAuthorship W2597757902A5034517280 @default.
- W2597757902 hasAuthorship W2597757902A5051474892 @default.
- W2597757902 hasAuthorship W2597757902A5058518849 @default.
- W2597757902 hasBestOaLocation W25977579021 @default.
- W2597757902 hasConcept C142724271 @default.
- W2597757902 hasConcept C147483822 @default.
- W2597757902 hasConcept C159047783 @default.
- W2597757902 hasConcept C159654299 @default.
- W2597757902 hasConcept C167508917 @default.
- W2597757902 hasConcept C203014093 @default.
- W2597757902 hasConcept C22070199 @default.
- W2597757902 hasConcept C2776525042 @default.
- W2597757902 hasConcept C2777648638 @default.
- W2597757902 hasConcept C2777691041 @default.
- W2597757902 hasConcept C2779134260 @default.
- W2597757902 hasConcept C2779261636 @default.
- W2597757902 hasConcept C2780801004 @default.
- W2597757902 hasConcept C3008058167 @default.
- W2597757902 hasConcept C524204448 @default.
- W2597757902 hasConcept C71924100 @default.
- W2597757902 hasConcept C86803240 @default.