Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597758295> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2597758295 abstract "ABSTRACT Neonatal infection with Streptococcus agalactiae (group B Streptococcus [GBS]) is a leading cause of sepsis and meningitis in newborns. Recent guidelines have recommended universal screening of all pregnant women to identify those colonized with GBS and administration of peripartum prophylaxis to those identified as carriers to reduce the risk of early-onset GBS disease in neonates. Enriched culture methods are the current standard for prenatal GBS screening; however, the implementation of more sensitive molecular diagnostic tests may be able to further reduce the risk of early-onset GBS infection. We report a clinical evaluation of the Xpert GBS LB assay, a molecular diagnostic test for the identification of GBS from broth-enriched vaginal/rectal specimens obtained during routine prenatal screening. A total of 826 specimens were collected from women undergoing prenatal screening (35 to 37 weeks9 gestation) and tested at one of three clinical centers. Each swab specimen was tested directly prior to enrichment using the Xpert GBS assay. Following 18 to 24 h of broth enrichment, each specimen was tested using the Xpert GBS LB assay and the FDA-cleared Smart GBS assay as a molecular diagnostic comparator. Results obtained using all three molecular tests were compared to those for broth-enriched culture as the gold standard. The sensitivity and specificity of the Xpert GBS LB assay were 99.0% and 92.4%, respectively, compared to those for the gold standard culture. The Smart GBS molecular test demonstrated sensitivity and specificity of 96.8% and 95.5%, respectively. The sensitivities of the two broth-enriched molecular methods were superior to those for direct testing of specimens using the Xpert GBS assay, which demonstrated sensitivity and specificity of 85.7% and 96.2%, respectively." @default.
- W2597758295 created "2017-04-07" @default.
- W2597758295 creator A5009854724 @default.
- W2597758295 creator A5026572686 @default.
- W2597758295 creator A5041037541 @default.
- W2597758295 creator A5056423854 @default.
- W2597758295 creator A5067044899 @default.
- W2597758295 creator A5077364637 @default.
- W2597758295 date "2015-02-01" @default.
- W2597758295 modified "2023-09-26" @default.
- W2597758295 title "Multicenter Clinical Evaluation of the Xpert GBS LB Assay for Detection of Group B Streptococcus in Prenatal Screening Specimens" @default.
- W2597758295 hasPublicationYear "2015" @default.
- W2597758295 type Work @default.
- W2597758295 sameAs 2597758295 @default.
- W2597758295 citedByCount "0" @default.
- W2597758295 crossrefType "journal-article" @default.
- W2597758295 hasAuthorship W2597758295A5009854724 @default.
- W2597758295 hasAuthorship W2597758295A5026572686 @default.
- W2597758295 hasAuthorship W2597758295A5041037541 @default.
- W2597758295 hasAuthorship W2597758295A5056423854 @default.
- W2597758295 hasAuthorship W2597758295A5067044899 @default.
- W2597758295 hasAuthorship W2597758295A5077364637 @default.
- W2597758295 hasConcept C126322002 @default.
- W2597758295 hasConcept C131872663 @default.
- W2597758295 hasConcept C172680121 @default.
- W2597758295 hasConcept C187212893 @default.
- W2597758295 hasConcept C2775953899 @default.
- W2597758295 hasConcept C2777785397 @default.
- W2597758295 hasConcept C2777860557 @default.
- W2597758295 hasConcept C2778258057 @default.
- W2597758295 hasConcept C2778276568 @default.
- W2597758295 hasConcept C2778384902 @default.
- W2597758295 hasConcept C2779234561 @default.
- W2597758295 hasConcept C2781026528 @default.
- W2597758295 hasConcept C40993552 @default.
- W2597758295 hasConcept C523546767 @default.
- W2597758295 hasConcept C54355233 @default.
- W2597758295 hasConcept C71924100 @default.
- W2597758295 hasConcept C86803240 @default.
- W2597758295 hasConceptScore W2597758295C126322002 @default.
- W2597758295 hasConceptScore W2597758295C131872663 @default.
- W2597758295 hasConceptScore W2597758295C172680121 @default.
- W2597758295 hasConceptScore W2597758295C187212893 @default.
- W2597758295 hasConceptScore W2597758295C2775953899 @default.
- W2597758295 hasConceptScore W2597758295C2777785397 @default.
- W2597758295 hasConceptScore W2597758295C2777860557 @default.
- W2597758295 hasConceptScore W2597758295C2778258057 @default.
- W2597758295 hasConceptScore W2597758295C2778276568 @default.
- W2597758295 hasConceptScore W2597758295C2778384902 @default.
- W2597758295 hasConceptScore W2597758295C2779234561 @default.
- W2597758295 hasConceptScore W2597758295C2781026528 @default.
- W2597758295 hasConceptScore W2597758295C40993552 @default.
- W2597758295 hasConceptScore W2597758295C523546767 @default.
- W2597758295 hasConceptScore W2597758295C54355233 @default.
- W2597758295 hasConceptScore W2597758295C71924100 @default.
- W2597758295 hasConceptScore W2597758295C86803240 @default.
- W2597758295 hasLocation W25977582951 @default.
- W2597758295 hasOpenAccess W2597758295 @default.
- W2597758295 hasPrimaryLocation W25977582951 @default.
- W2597758295 hasRelatedWork W2018959609 @default.
- W2597758295 hasRelatedWork W2052798211 @default.
- W2597758295 hasRelatedWork W2077435164 @default.
- W2597758295 hasRelatedWork W2121030778 @default.
- W2597758295 hasRelatedWork W2268971997 @default.
- W2597758295 hasRelatedWork W2608968597 @default.
- W2597758295 hasRelatedWork W2610713042 @default.
- W2597758295 hasRelatedWork W2740280240 @default.
- W2597758295 hasRelatedWork W2755479058 @default.
- W2597758295 hasRelatedWork W2786526597 @default.
- W2597758295 hasRelatedWork W2804515239 @default.
- W2597758295 hasRelatedWork W2930729520 @default.
- W2597758295 hasRelatedWork W2945563788 @default.
- W2597758295 hasRelatedWork W2969469247 @default.
- W2597758295 hasRelatedWork W2970181489 @default.
- W2597758295 hasRelatedWork W2976510273 @default.
- W2597758295 hasRelatedWork W3035554312 @default.
- W2597758295 hasRelatedWork W3139538929 @default.
- W2597758295 hasRelatedWork W3201380114 @default.
- W2597758295 hasRelatedWork W2107037160 @default.
- W2597758295 isParatext "false" @default.
- W2597758295 isRetracted "false" @default.
- W2597758295 magId "2597758295" @default.
- W2597758295 workType "article" @default.