Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597763745> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2597763745 abstract "markdownabstractT-cell acute lymphoblastic leukemia (T-ALL) represents 10-15% of pediatric acute leukemias. Despite major therapeutic improvements due to treatment intensification and refined risk-adapted stratification during the past decade, ~30% of T-ALL cases relapse with very poor prognosis. T-cell transformation is characterized by aberrant expression of oncogenic transcription factors combined with inactivation of tumor suppressor genes (e.g. PTEN, CDKN2A) and/or activation of the NOTCH1 pathway. The ectopic expression of oncogenes is typically caused by chromosomal rearrangements that place oncogenes under the control of T-cell specific promoters or enhancer elements. This thesis aimed to: 1) identify additional PTEN-inactivating events as novel type-B mutations that may provide survival and proliferation advantage to (pre)-leukemic cells, and understand their clinical impact in T-ALL; 2) establish an in vitro co-culture system (OP9-DL1) that supports T-cell development from human umbilical cord blood-derived hematopoietic stem cells (HSCs), with the intention of defining distinct human T-cell development stages in relation to the underlying transcriptional programs and expression of cell surface markers; 3) optimize a lentivirus system that supports transduction and stable expression of oncogenes in human and mouse HSCs and 4) study the impact of ETP-ALL expressed oncogenes (such as MEF2C, LYL1 or LMO2) on human T-cell development using the OP9-DL1 in vitro system" @default.
- W2597763745 created "2017-04-07" @default.
- W2597763745 creator A5026560966 @default.
- W2597763745 date "2016-12-13" @default.
- W2597763745 modified "2023-09-23" @default.
- W2597763745 title "Unravelling Pathobiological Molecular Mechanisms of T-Cell Acute Lymphoblastic Leukemia" @default.
- W2597763745 cites W2120746509 @default.
- W2597763745 hasPublicationYear "2016" @default.
- W2597763745 type Work @default.
- W2597763745 sameAs 2597763745 @default.
- W2597763745 citedByCount "0" @default.
- W2597763745 crossrefType "journal-article" @default.
- W2597763745 hasAuthorship W2597763745A5026560966 @default.
- W2597763745 hasConcept C109159458 @default.
- W2597763745 hasConcept C203014093 @default.
- W2597763745 hasConcept C2776090121 @default.
- W2597763745 hasConcept C2777609662 @default.
- W2597763745 hasConcept C28328180 @default.
- W2597763745 hasConcept C502942594 @default.
- W2597763745 hasConcept C54355233 @default.
- W2597763745 hasConcept C62112901 @default.
- W2597763745 hasConcept C62478195 @default.
- W2597763745 hasConcept C81885089 @default.
- W2597763745 hasConcept C86554907 @default.
- W2597763745 hasConcept C86803240 @default.
- W2597763745 hasConcept C8891405 @default.
- W2597763745 hasConcept C95444343 @default.
- W2597763745 hasConcept C97037327 @default.
- W2597763745 hasConceptScore W2597763745C109159458 @default.
- W2597763745 hasConceptScore W2597763745C203014093 @default.
- W2597763745 hasConceptScore W2597763745C2776090121 @default.
- W2597763745 hasConceptScore W2597763745C2777609662 @default.
- W2597763745 hasConceptScore W2597763745C28328180 @default.
- W2597763745 hasConceptScore W2597763745C502942594 @default.
- W2597763745 hasConceptScore W2597763745C54355233 @default.
- W2597763745 hasConceptScore W2597763745C62112901 @default.
- W2597763745 hasConceptScore W2597763745C62478195 @default.
- W2597763745 hasConceptScore W2597763745C81885089 @default.
- W2597763745 hasConceptScore W2597763745C86554907 @default.
- W2597763745 hasConceptScore W2597763745C86803240 @default.
- W2597763745 hasConceptScore W2597763745C8891405 @default.
- W2597763745 hasConceptScore W2597763745C95444343 @default.
- W2597763745 hasConceptScore W2597763745C97037327 @default.
- W2597763745 hasLocation W25977637451 @default.
- W2597763745 hasOpenAccess W2597763745 @default.
- W2597763745 hasPrimaryLocation W25977637451 @default.
- W2597763745 hasRelatedWork W2007240193 @default.
- W2597763745 hasRelatedWork W2039793795 @default.
- W2597763745 hasRelatedWork W2075542228 @default.
- W2597763745 hasRelatedWork W2084503373 @default.
- W2597763745 hasRelatedWork W2089686547 @default.
- W2597763745 hasRelatedWork W2101129521 @default.
- W2597763745 hasRelatedWork W2107552389 @default.
- W2597763745 hasRelatedWork W2129441797 @default.
- W2597763745 hasRelatedWork W2165896516 @default.
- W2597763745 hasRelatedWork W2344604745 @default.
- W2597763745 hasRelatedWork W2393571430 @default.
- W2597763745 hasRelatedWork W2554189916 @default.
- W2597763745 hasRelatedWork W2580215615 @default.
- W2597763745 hasRelatedWork W2599031674 @default.
- W2597763745 hasRelatedWork W2778290456 @default.
- W2597763745 hasRelatedWork W2779965943 @default.
- W2597763745 hasRelatedWork W2901085249 @default.
- W2597763745 hasRelatedWork W3108862937 @default.
- W2597763745 hasRelatedWork W3184359261 @default.
- W2597763745 hasRelatedWork W2474977813 @default.
- W2597763745 isParatext "false" @default.
- W2597763745 isRetracted "false" @default.
- W2597763745 magId "2597763745" @default.
- W2597763745 workType "article" @default.