Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597804586> ?p ?o ?g. }
- W2597804586 endingPage "9" @default.
- W2597804586 startingPage "1" @default.
- W2597804586 abstract "ADP-ribosylation factors (Arfs) are members of the Ras GTPase superfamily. The function of Arfs is dependent on GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), which allow Arfs to cycle between the GDP-bound and GTP-bound forms. Arf GAPs have been shown to be present in integrin adhesion complexes, which include focal adhesions. Integrin adhesion complexes are composed of integrins, scaffolding proteins and signaling proteins and regulate cell proliferation, survival, differentiation and migration. Understanding the role of Arf GAPs in the regulation of integrin adhesion complexes is relevant to understanding normal physiology and cancer. In this review, we will discuss the contribution of the Arf GAP family members to the regulation of integrin adhesion complexes, examining the diverse mechanisms by which they control integrin adhesion complex formation, maturation and dissolution. GIT1 and ARAP2 serve as GAPs for Arf6, regulating Rac1 and other effectors by mechanisms still being defined. In contrast, GIT2 regulates Rac1 independent of Arf6. AGAP2 binds to and regulates focal adhesion kinase (FAK). ARAP2 and ACAP1, both Arf6 GAPs, regulate membrane trafficking of integrins through different endocytic pathways, exerting opposite effects on focal adhesions. ASAP1 not only regulates actin cytoskeleton remodeling through its interaction with nonmuscle myosin 2A, but is also important in integrin recycling. These examples illustrate the diversity and versatility of Arf GAPs as regulators of integrin adhesion complex structure and function." @default.
- W2597804586 created "2017-04-07" @default.
- W2597804586 creator A5004574231 @default.
- W2597804586 creator A5009326851 @default.
- W2597804586 creator A5017037310 @default.
- W2597804586 creator A5061371289 @default.
- W2597804586 date "2017-03-31" @default.
- W2597804586 modified "2023-10-12" @default.
- W2597804586 title "Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex" @default.
- W2597804586 cites W1490141102 @default.
- W2597804586 cites W1500612905 @default.
- W2597804586 cites W1544613378 @default.
- W2597804586 cites W1576773659 @default.
- W2597804586 cites W1811064827 @default.
- W2597804586 cites W1826668344 @default.
- W2597804586 cites W1964252660 @default.
- W2597804586 cites W1968815565 @default.
- W2597804586 cites W1972422664 @default.
- W2597804586 cites W1974406469 @default.
- W2597804586 cites W1977152640 @default.
- W2597804586 cites W1979038578 @default.
- W2597804586 cites W1980506609 @default.
- W2597804586 cites W1982149350 @default.
- W2597804586 cites W1984872320 @default.
- W2597804586 cites W1990915902 @default.
- W2597804586 cites W1999151951 @default.
- W2597804586 cites W2001303884 @default.
- W2597804586 cites W2001339111 @default.
- W2597804586 cites W2002982362 @default.
- W2597804586 cites W2009023199 @default.
- W2597804586 cites W2009468127 @default.
- W2597804586 cites W2010618491 @default.
- W2597804586 cites W2012678565 @default.
- W2597804586 cites W2030029307 @default.
- W2597804586 cites W2030284897 @default.
- W2597804586 cites W2031458588 @default.
- W2597804586 cites W2034833395 @default.
- W2597804586 cites W2036875727 @default.
- W2597804586 cites W2038998037 @default.
- W2597804586 cites W2048209624 @default.
- W2597804586 cites W2049638147 @default.
- W2597804586 cites W2049804931 @default.
- W2597804586 cites W2061006256 @default.
- W2597804586 cites W2065264929 @default.
- W2597804586 cites W2065473452 @default.
- W2597804586 cites W2067807852 @default.
- W2597804586 cites W2068358300 @default.
- W2597804586 cites W2075210551 @default.
- W2597804586 cites W2076950591 @default.
- W2597804586 cites W2079595896 @default.
- W2597804586 cites W2086405676 @default.
- W2597804586 cites W2086681436 @default.
- W2597804586 cites W2087963453 @default.
- W2597804586 cites W2092954353 @default.
- W2597804586 cites W2094099329 @default.
- W2597804586 cites W2098436412 @default.
- W2597804586 cites W2100793419 @default.
- W2597804586 cites W2100979233 @default.
- W2597804586 cites W2102226328 @default.
- W2597804586 cites W2108861663 @default.
- W2597804586 cites W2110246051 @default.
- W2597804586 cites W2112652451 @default.
- W2597804586 cites W2116659145 @default.
- W2597804586 cites W2117111749 @default.
- W2597804586 cites W2124169597 @default.
- W2597804586 cites W2125217376 @default.
- W2597804586 cites W2125282776 @default.
- W2597804586 cites W2127432085 @default.
- W2597804586 cites W2135502056 @default.
- W2597804586 cites W2145392559 @default.
- W2597804586 cites W2149532912 @default.
- W2597804586 cites W2151624014 @default.
- W2597804586 cites W2152348521 @default.
- W2597804586 cites W2155151508 @default.
- W2597804586 cites W2157647165 @default.
- W2597804586 cites W2162752530 @default.
- W2597804586 cites W2166782826 @default.
- W2597804586 cites W2174885573 @default.
- W2597804586 cites W2280240311 @default.
- W2597804586 cites W2325225342 @default.
- W2597804586 cites W2382722815 @default.
- W2597804586 cites W2387420602 @default.
- W2597804586 cites W2419141319 @default.
- W2597804586 cites W2509457056 @default.
- W2597804586 cites W2510134364 @default.
- W2597804586 cites W4213174658 @default.
- W2597804586 doi "https://doi.org/10.1080/21541248.2017.1299271" @default.
- W2597804586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548304" @default.
- W2597804586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28362242" @default.
- W2597804586 hasPublicationYear "2017" @default.
- W2597804586 type Work @default.
- W2597804586 sameAs 2597804586 @default.
- W2597804586 citedByCount "19" @default.
- W2597804586 countsByYear W25978045862018 @default.
- W2597804586 countsByYear W25978045862019 @default.
- W2597804586 countsByYear W25978045862020 @default.
- W2597804586 countsByYear W25978045862021 @default.
- W2597804586 countsByYear W25978045862022 @default.