Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597805329> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2597805329 abstract "4586 Background: Limited data exists on outcomes for mRCC patients treated with multiple lines of therapy. Benchmarks for survival are required for patient counseling and clinical trial design. Methods: Outcomes of mRCC patients from the IMDC treated with 1, 2, or 3+ lines of targeted therapy (TT) were compared and adjusted by proportional hazards regression. Overall survival (OS) and progression-free survival (PFS) benchmarks were calculated using different population inclusion criteria. OS and PFS are calculated from the line of therapy under consideration unless otherwise specified. Results: 2,705 patients were treated with TT of which 1,533 (57%) received only 1st-line TT, 734 (27%) received 2 lines of TT, and 438 (16%) received 3+ lines of TT. The median OS of patients that received 1, 2 or 3+ lines of TT starting from initial TT was 14.9, 21.0, and 39.2 months, respectively (p<0.0001). On multivariable analysis adjusting for baseline Heng prognostic factors, the use of 2nd-line and 3rd-line therapy were each independently associated with better OS (HR=0.738 and 0.626, respectively, both p<0.0001). Survival benchmarks derived from patients in the IMDC using selected inclusion criteria as seen in contemporary mRCC clinical trials are shown below. Conclusions: Patients that are able to receive more lines of TT live longer. Survival benchmarks provide context and perspective when interpreting and designing new clinical trials. [Table: see text]" @default.
- W2597805329 created "2017-04-07" @default.
- W2597805329 creator A5024173107 @default.
- W2597805329 creator A5024676627 @default.
- W2597805329 creator A5025529463 @default.
- W2597805329 creator A5033181043 @default.
- W2597805329 creator A5036351512 @default.
- W2597805329 creator A5037646183 @default.
- W2597805329 creator A5041033274 @default.
- W2597805329 creator A5045869380 @default.
- W2597805329 creator A5052504518 @default.
- W2597805329 creator A5055738663 @default.
- W2597805329 creator A5059200225 @default.
- W2597805329 creator A5061626918 @default.
- W2597805329 creator A5063838757 @default.
- W2597805329 creator A5068644454 @default.
- W2597805329 creator A5069683592 @default.
- W2597805329 creator A5073593424 @default.
- W2597805329 creator A5077514210 @default.
- W2597805329 creator A5080507578 @default.
- W2597805329 creator A5087836779 @default.
- W2597805329 creator A5089375452 @default.
- W2597805329 date "2013-05-20" @default.
- W2597805329 modified "2023-09-24" @default.
- W2597805329 title "First-, second-, third-line therapy for metastatic renal cell carcinoma (mRCC): Benchmarks for trials design from the International mRCC Database Consortium (IMDC)." @default.
- W2597805329 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.4586" @default.
- W2597805329 hasPublicationYear "2013" @default.
- W2597805329 type Work @default.
- W2597805329 sameAs 2597805329 @default.
- W2597805329 citedByCount "1" @default.
- W2597805329 countsByYear W25978053292014 @default.
- W2597805329 crossrefType "journal-article" @default.
- W2597805329 hasAuthorship W2597805329A5024173107 @default.
- W2597805329 hasAuthorship W2597805329A5024676627 @default.
- W2597805329 hasAuthorship W2597805329A5025529463 @default.
- W2597805329 hasAuthorship W2597805329A5033181043 @default.
- W2597805329 hasAuthorship W2597805329A5036351512 @default.
- W2597805329 hasAuthorship W2597805329A5037646183 @default.
- W2597805329 hasAuthorship W2597805329A5041033274 @default.
- W2597805329 hasAuthorship W2597805329A5045869380 @default.
- W2597805329 hasAuthorship W2597805329A5052504518 @default.
- W2597805329 hasAuthorship W2597805329A5055738663 @default.
- W2597805329 hasAuthorship W2597805329A5059200225 @default.
- W2597805329 hasAuthorship W2597805329A5061626918 @default.
- W2597805329 hasAuthorship W2597805329A5063838757 @default.
- W2597805329 hasAuthorship W2597805329A5068644454 @default.
- W2597805329 hasAuthorship W2597805329A5069683592 @default.
- W2597805329 hasAuthorship W2597805329A5073593424 @default.
- W2597805329 hasAuthorship W2597805329A5077514210 @default.
- W2597805329 hasAuthorship W2597805329A5080507578 @default.
- W2597805329 hasAuthorship W2597805329A5087836779 @default.
- W2597805329 hasAuthorship W2597805329A5089375452 @default.
- W2597805329 hasConcept C126322002 @default.
- W2597805329 hasConcept C143998085 @default.
- W2597805329 hasConcept C2775832928 @default.
- W2597805329 hasConcept C2777472916 @default.
- W2597805329 hasConcept C71924100 @default.
- W2597805329 hasConceptScore W2597805329C126322002 @default.
- W2597805329 hasConceptScore W2597805329C143998085 @default.
- W2597805329 hasConceptScore W2597805329C2775832928 @default.
- W2597805329 hasConceptScore W2597805329C2777472916 @default.
- W2597805329 hasConceptScore W2597805329C71924100 @default.
- W2597805329 hasLocation W25978053291 @default.
- W2597805329 hasOpenAccess W2597805329 @default.
- W2597805329 hasPrimaryLocation W25978053291 @default.
- W2597805329 hasRelatedWork W1995840808 @default.
- W2597805329 hasRelatedWork W2184946578 @default.
- W2597805329 hasRelatedWork W2227116226 @default.
- W2597805329 hasRelatedWork W2590868182 @default.
- W2597805329 hasRelatedWork W2600306685 @default.
- W2597805329 hasRelatedWork W2735513009 @default.
- W2597805329 hasRelatedWork W2782110733 @default.
- W2597805329 hasRelatedWork W2890521087 @default.
- W2597805329 hasRelatedWork W2892001203 @default.
- W2597805329 hasRelatedWork W2896057849 @default.
- W2597805329 hasRelatedWork W2921483392 @default.
- W2597805329 hasRelatedWork W2953688847 @default.
- W2597805329 hasRelatedWork W2954954143 @default.
- W2597805329 hasRelatedWork W2964700995 @default.
- W2597805329 hasRelatedWork W2977743112 @default.
- W2597805329 hasRelatedWork W2996164021 @default.
- W2597805329 hasRelatedWork W3006846003 @default.
- W2597805329 hasRelatedWork W3007983591 @default.
- W2597805329 hasRelatedWork W3028956426 @default.
- W2597805329 hasRelatedWork W3032079924 @default.
- W2597805329 isParatext "false" @default.
- W2597805329 isRetracted "false" @default.
- W2597805329 magId "2597805329" @default.
- W2597805329 workType "article" @default.