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- W2597827857 abstract "Most bladder tumors have complex genomes characterized by a high mutation burden as well as frequent copy number alterations and chromosomal rearrangements. Alterations in DNA repair pathways-including the double-strand break (DSB) and nucleotide excision repair (NER) pathways-are present in bladder tumors and may contribute to genomic instability and drive the tumor phenotype. DNA damaging such as cisplatin, mitomycin C, and radiation are commonly used in the treatment of muscle-invasive or metastatic bladder cancer, and several recent studies have linked specific DNA repair pathway defects with sensitivity to DNA damaging-based therapy. In addition, tumor DNA repair defects have important implications for use of immunotherapy and other targeted agents in bladder cancer. Therefore, efforts to further understand the landscape of DNA repair alterations in bladder cancer will be critical in advancing treatment for bladder cancer. This review summarizes the current understanding of the role of DNA repair pathway alterations in bladder tumor biology and response to therapy." @default.
- W2597827857 created "2017-04-07" @default.
- W2597827857 creator A5073123534 @default.
- W2597827857 date "2017-03-27" @default.
- W2597827857 modified "2023-10-03" @default.
- W2597827857 title "DNA Repair Pathway Alterations in Bladder Cancer" @default.
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- W2597827857 doi "https://doi.org/10.3390/cancers9040028" @default.
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