Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597907274> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2597907274 endingPage "2490" @default.
- W2597907274 startingPage "2486" @default.
- W2597907274 abstract "Objective: Nasopharyngeal carcinoma is a common malignant tumor. This study aims to explore the inhibitory effect and mechanism of trimethoxy stilbene on human nasopharyngeal carcinoma cells.Methods: Human nasopharyngeal carcinoma cells, CNE1 and 5-8F, in logarithmic phase were collected and inoculated in a 96 pore cell culture plate. Cells were treated with 100 μl of culture media containing 2, 5, 10, or 20 mM of trimethoxy stilbene. MTT was added to each pore after 72 h of continuous cell culture. The absorbance value of each pore was detected at 490 nm by a micro plate reader. CNE1 and 5-8 F cells in logarithmic phase were inoculated in 6 pore cell culture plates. Cells were treated with 100 μl culture media containing 2, 5, 10, or 20 mM of trimethoxy stilbene. Cells cultured for two weeks or 24 h were stained with crystal violet. Photographic images were taken by a digital camera and recorded. Cell cloning was quantitatively analysed with quantity one (Bio-Rad). Annexin V-FITC and PT solution were added to the cell cultures. The mixture was then incubated under ambient temperature for 15 min.Results: Cisplatin IC50 values of CNE1 and 5-8F cells processed with 20 μmol/L trimethoxy stilbene were evidently lower than that of the control group processed with 0 μmol/L trimethoxy stilbene. In addition, treatment with combined cisplatin and trimethoxy stilbene induced higher rates of apoptosis in CNE1 and 5-8F cells compared with only trimethoxy stilbene or cisplatin. The proportion of cells in G0/G1 phase increased as drug concentration increased. A concentration-effect relationship was observed, indicating that trimethoxy stilbene induced G2/M phase arrest in drug-resistant nasopharyngeal carcinoma cells.Conclusion: Trimethoxy stilbene significantly inhibited the in-vitro proliferation capacity and clone formation ability of nasopharyngeal carcinoma cells. This inhibitory effect might be realized by inducing nasopharyngeal carcinoma cells to enter G2/M arrest." @default.
- W2597907274 created "2017-04-07" @default.
- W2597907274 creator A5067093084 @default.
- W2597907274 creator A5080968713 @default.
- W2597907274 creator A5090484803 @default.
- W2597907274 date "2017-01-01" @default.
- W2597907274 modified "2023-09-22" @default.
- W2597907274 title "Trimethoxy stilbene regulates the nasopharyngeal carcinoma cell apoptosis pathway and enhances sensitization to cisplatin-based chemotherapy" @default.
- W2597907274 cites W1991968799 @default.
- W2597907274 cites W1997391888 @default.
- W2597907274 cites W2057749060 @default.
- W2597907274 cites W2059775855 @default.
- W2597907274 cites W2111247797 @default.
- W2597907274 cites W2134749755 @default.
- W2597907274 cites W2136080892 @default.
- W2597907274 hasPublicationYear "2017" @default.
- W2597907274 type Work @default.
- W2597907274 sameAs 2597907274 @default.
- W2597907274 citedByCount "0" @default.
- W2597907274 crossrefType "journal-article" @default.
- W2597907274 hasAuthorship W2597907274A5067093084 @default.
- W2597907274 hasAuthorship W2597907274A5080968713 @default.
- W2597907274 hasAuthorship W2597907274A5090484803 @default.
- W2597907274 hasConcept C126322002 @default.
- W2597907274 hasConcept C142724271 @default.
- W2597907274 hasConcept C1491633281 @default.
- W2597907274 hasConcept C153911025 @default.
- W2597907274 hasConcept C185592680 @default.
- W2597907274 hasConcept C190283241 @default.
- W2597907274 hasConcept C2776694085 @default.
- W2597907274 hasConcept C2778239845 @default.
- W2597907274 hasConcept C2778997737 @default.
- W2597907274 hasConcept C2780783641 @default.
- W2597907274 hasConcept C509974204 @default.
- W2597907274 hasConcept C54355233 @default.
- W2597907274 hasConcept C55493867 @default.
- W2597907274 hasConcept C71924100 @default.
- W2597907274 hasConcept C74864618 @default.
- W2597907274 hasConcept C81885089 @default.
- W2597907274 hasConcept C86803240 @default.
- W2597907274 hasConceptScore W2597907274C126322002 @default.
- W2597907274 hasConceptScore W2597907274C142724271 @default.
- W2597907274 hasConceptScore W2597907274C1491633281 @default.
- W2597907274 hasConceptScore W2597907274C153911025 @default.
- W2597907274 hasConceptScore W2597907274C185592680 @default.
- W2597907274 hasConceptScore W2597907274C190283241 @default.
- W2597907274 hasConceptScore W2597907274C2776694085 @default.
- W2597907274 hasConceptScore W2597907274C2778239845 @default.
- W2597907274 hasConceptScore W2597907274C2778997737 @default.
- W2597907274 hasConceptScore W2597907274C2780783641 @default.
- W2597907274 hasConceptScore W2597907274C509974204 @default.
- W2597907274 hasConceptScore W2597907274C54355233 @default.
- W2597907274 hasConceptScore W2597907274C55493867 @default.
- W2597907274 hasConceptScore W2597907274C71924100 @default.
- W2597907274 hasConceptScore W2597907274C74864618 @default.
- W2597907274 hasConceptScore W2597907274C81885089 @default.
- W2597907274 hasConceptScore W2597907274C86803240 @default.
- W2597907274 hasIssue "6" @default.
- W2597907274 hasLocation W25979072741 @default.
- W2597907274 hasOpenAccess W2597907274 @default.
- W2597907274 hasPrimaryLocation W25979072741 @default.
- W2597907274 hasRelatedWork W1984829707 @default.
- W2597907274 hasRelatedWork W1999867736 @default.
- W2597907274 hasRelatedWork W200947224 @default.
- W2597907274 hasRelatedWork W2348043463 @default.
- W2597907274 hasRelatedWork W2353424248 @default.
- W2597907274 hasRelatedWork W2355435650 @default.
- W2597907274 hasRelatedWork W2359691490 @default.
- W2597907274 hasRelatedWork W2359848468 @default.
- W2597907274 hasRelatedWork W2364542117 @default.
- W2597907274 hasRelatedWork W2375328125 @default.
- W2597907274 hasRelatedWork W2377244429 @default.
- W2597907274 hasRelatedWork W2378119109 @default.
- W2597907274 hasRelatedWork W2380765184 @default.
- W2597907274 hasRelatedWork W2381671650 @default.
- W2597907274 hasRelatedWork W2383212314 @default.
- W2597907274 hasRelatedWork W2389591253 @default.
- W2597907274 hasRelatedWork W2392224847 @default.
- W2597907274 hasRelatedWork W2392372809 @default.
- W2597907274 hasRelatedWork W2393435026 @default.
- W2597907274 hasRelatedWork W2394364159 @default.
- W2597907274 hasVolume "28" @default.
- W2597907274 isParatext "false" @default.
- W2597907274 isRetracted "false" @default.
- W2597907274 magId "2597907274" @default.
- W2597907274 workType "article" @default.