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- W2598020765 abstract "In echinoderms, major morphological transitions during early development are attributed to different genetic interactions and changes in global expression patterns that shape the regulatory program for the specification of embryonic territories. In order more thoroughly to understand these biological and molecular processes, we examined the transcriptome structure and expression profiles during the embryo-to-larva transition of a keystone species, the giant red sea urchin Mesocentrotus franciscanus. Using a de novo assembly approach, we obtained 176,885 transcripts from which 60,439 (34%) had significant alignments to known proteins. From these transcripts, ~80% were functionally annotated allowing the identification of ~2,600 functional, structural, and regulatory genes involved in developmental process. Analysis of expression profiles between gastrula and pluteus stages of M. franciscanus revealed 791 differentially expressed genes with 251 GO overrepresented terms. For gastrula, up-regulated GO terms were mainly linked to cell differentiation and signal transduction involved in cell cycle checkpoints. In the pluteus stage, major GO terms were associated with phosphoprotein phosphatase activity, muscle contraction, and olfactory behavior, among others. Our evolutionary comparative analysis revealed that several of these genes and functional pathways are highly conserved among echinoids, holothuroids, and ophiuroids." @default.
- W2598020765 created "2017-04-07" @default.
- W2598020765 creator A5032164548 @default.
- W2598020765 creator A5043990517 @default.
- W2598020765 date "2017-03-21" @default.
- W2598020765 modified "2023-09-25" @default.
- W2598020765 title "Gene expression profiling during the embryo-to-larva transition in the giant red sea urchin<i>Mesocentrotus franciscanus</i>" @default.
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- W2598020765 doi "https://doi.org/10.1002/ece3.2850" @default.
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