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- W2598033973 abstract "Endophytic actinobacteria, which reside in the inner tissues of host plants, are gaining serious attention due to their capacity to produce a plethora of secondary metabolites (e.g. antibiotics) possessing a wide variety of biological activity with diverse functions. This review encompasses the recent reports on endophytic actinobacterial species diversity, in planta habitats and mechanisms underlying their mode of entry into plants. Besides, their metabolic potential, novel bioactive compounds they produce and mechanisms to unravel their hidden metabolic repertoire by activation of cryptic or silent biosynthetic gene clusters (BGCs) for eliciting novel secondary metabolite production are discussed. The study also reviews the classical conservative techniques (chemical/biological/physical elicitation, co-culturing) as well as modern microbiology tools (e.g. next generation sequencing) that are being gainfully employed to uncover the vast hidden scaffolds for novel secondary metabolites produced by these endophytes, which would subsequently herald a revolution in drug engineering. The potential role of these endophytes in the agro-environment as promising biological candidates for inhibition of phytopathogens and the way forward to thoroughly exploit this unique microbial community by inducing expression of cryptic BGCs for encoding unseen products with novel therapeutic properties are also discussed." @default.
- W2598033973 created "2017-04-07" @default.
- W2598033973 creator A5001393138 @default.
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- W2598033973 creator A5060804436 @default.
- W2598033973 creator A5068102516 @default.
- W2598033973 creator A5076938736 @default.
- W2598033973 date "2017-03-30" @default.
- W2598033973 modified "2023-10-16" @default.
- W2598033973 title "Endophytic actinobacteria: Diversity, secondary metabolism and mechanisms to unsilence biosynthetic gene clusters" @default.
- W2598033973 cites W1023183953 @default.
- W2598033973 cites W1202680985 @default.
- W2598033973 cites W1505309374 @default.
- W2598033973 cites W1548832028 @default.
- W2598033973 cites W1575478532 @default.
- W2598033973 cites W1591613877 @default.
- W2598033973 cites W1683352839 @default.
- W2598033973 cites W1744149475 @default.
- W2598033973 cites W1801344600 @default.
- W2598033973 cites W1826398152 @default.
- W2598033973 cites W1827213771 @default.
- W2598033973 cites W1868778935 @default.
- W2598033973 cites W1922749943 @default.
- W2598033973 cites W1963629065 @default.
- W2598033973 cites W1965783027 @default.
- W2598033973 cites W1968152424 @default.
- W2598033973 cites W1972150771 @default.
- W2598033973 cites W1973028918 @default.
- W2598033973 cites W1973507391 @default.
- W2598033973 cites W1974235911 @default.
- W2598033973 cites W1977216378 @default.
- W2598033973 cites W1977271869 @default.
- W2598033973 cites W1977659243 @default.
- W2598033973 cites W1978590167 @default.
- W2598033973 cites W1980498900 @default.
- W2598033973 cites W1982718903 @default.
- W2598033973 cites W1984523732 @default.
- W2598033973 cites W1986933796 @default.
- W2598033973 cites W1988815096 @default.
- W2598033973 cites W1990387736 @default.
- W2598033973 cites W1994714516 @default.
- W2598033973 cites W1996844058 @default.
- W2598033973 cites W1997421690 @default.
- W2598033973 cites W1999995951 @default.
- W2598033973 cites W2000661555 @default.
- W2598033973 cites W2002760375 @default.
- W2598033973 cites W2004732016 @default.
- W2598033973 cites W2005424731 @default.
- W2598033973 cites W200642257 @default.
- W2598033973 cites W2008030138 @default.
- W2598033973 cites W2008353386 @default.
- W2598033973 cites W2008612347 @default.
- W2598033973 cites W2009149393 @default.
- W2598033973 cites W2009156161 @default.
- W2598033973 cites W2012960603 @default.
- W2598033973 cites W2014066127 @default.
- W2598033973 cites W2015134245 @default.
- W2598033973 cites W2015365537 @default.
- W2598033973 cites W2017387862 @default.
- W2598033973 cites W2017434558 @default.
- W2598033973 cites W2018624125 @default.
- W2598033973 cites W2019743723 @default.
- W2598033973 cites W2020161436 @default.
- W2598033973 cites W2023192368 @default.
- W2598033973 cites W2025596155 @default.
- W2598033973 cites W2028548865 @default.
- W2598033973 cites W2029779699 @default.
- W2598033973 cites W2030313691 @default.
- W2598033973 cites W2030424754 @default.
- W2598033973 cites W2032695732 @default.
- W2598033973 cites W2034475154 @default.
- W2598033973 cites W2037181485 @default.
- W2598033973 cites W2038116915 @default.
- W2598033973 cites W2040757158 @default.
- W2598033973 cites W2041537722 @default.
- W2598033973 cites W2042094696 @default.
- W2598033973 cites W2043381813 @default.
- W2598033973 cites W2050139567 @default.
- W2598033973 cites W2054617297 @default.
- W2598033973 cites W2056999512 @default.
- W2598033973 cites W2057969236 @default.
- W2598033973 cites W2058537280 @default.
- W2598033973 cites W2060691992 @default.
- W2598033973 cites W2061723627 @default.
- W2598033973 cites W2061843938 @default.
- W2598033973 cites W2064466082 @default.
- W2598033973 cites W2064651289 @default.
- W2598033973 cites W2065648394 @default.
- W2598033973 cites W2066127448 @default.
- W2598033973 cites W2066550363 @default.
- W2598033973 cites W2067903267 @default.
- W2598033973 cites W2068287003 @default.
- W2598033973 cites W2070187090 @default.
- W2598033973 cites W2071210872 @default.
- W2598033973 cites W2074172008 @default.
- W2598033973 cites W2074497336 @default.
- W2598033973 cites W2074907602 @default.
- W2598033973 cites W2077035664 @default.