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- W2598045563 endingPage "88" @default.
- W2598045563 startingPage "81" @default.
- W2598045563 abstract "Abstract Background Infertility affects about 15% of couples who wish to have children and half of these cases are associated with male factors. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions, and specific mutations/deletions of several Y chromosome genes. Many researchers have analyzed genes in the AZF region on the Y chromosome; however, in 2003 the SYCP 3 gene on chromosome 12 (12q23) was identified as causing azoospermia by meiotic arrest through a point mutation. Methods We mainly describe the SYCP 3 and PLK 4 genes that we have studied in our laboratory, and add comments on other genes associated with human male infertility. Results Up to now, The 17 genes causing male infertility by their mutation have been reported in human. Conclusions Infertility caused by nonobstructive azoospermia ( NOA ) is very important in the field of assisted reproductive technology. Even with the aid of chromosomal analysis, ultrasonography of the testis, and detailed endocrinology, only MD ‐ TESE can confirm the presence of immature spermatozoa in the testes. We strongly hope that these studies help clinics avoid ineffective MD ‐ TESE procedures." @default.
- W2598045563 created "2017-04-07" @default.
- W2598045563 creator A5003537138 @default.
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- W2598045563 creator A5054736034 @default.
- W2598045563 creator A5073556065 @default.
- W2598045563 creator A5083155458 @default.
- W2598045563 date "2017-03-26" @default.
- W2598045563 modified "2023-10-03" @default.
- W2598045563 title "Human male infertility and its genetic causes" @default.
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