FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2598049088> ?p ?o ?g. }

• W2598049088 endingPage "634" @default.
• W2598049088 startingPage "624" @default.
• W2598049088 abstract "FVB mice are extensively used in transgenic and pharmacokinetic research. In this study, a validated isotope label-free method was constructed using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to quantify 24 drug-metabolizing enzymes (DMEs) in FVB mice. The DMEs include cytochrome P450s (CYP450s/Cyp450s), UDP-glucuronsyltransferases (UGTs/Ugts), and sulfotransferases (SULTs/Sults), which catalyze a variety of reactions to detoxify xenobiotics and endobiotics. The proposed UHPLC-MS/MS method exhibited good range and high sensitivity for signature peptides, as well as acceptable accuracy, precision, and recovery. The protein expression profiles of the DMEs were determined in male and female mice. Overall, the major Cyps, Ugts, and Sults were expressed in male mice followed the rank order: Cyp2c29 > 2e1 > 3a11 > 1a2 > 2d22 > 27a1 > 2c39; Ugt2b5 > 2b1 > 1a6a > 1a9 > 1a1 > 2a3 > 1a2 > 1a5; and Sult1a1 > 3a > 1d1. In contrast, the rank order in female mice was Cyp2c29 > 2e1 > 2c39 > 2d22 > 3a11 > 1a2 > 27a1; Ugt1a6a > 2b5 > 1a1 > 2b1 > 2a3 > 1a9 > 1a5 > 1a2; and Sult1a1 > 3a1 > 1d1. Cyp2c29, Cyp1a2, Cyp27a1, Ugt2b1, Ugt2b5 and Ugt2b36 were male predominant, whereas Cyp2c39, Cyp2d22, Cyp7a1, Ugt1a1, Ugt1a5, Sult1a1, Sult3a1, and Sult1d1 were female predominant. This work could serve as a useful reference for the metabolic study of new drugs and for elucidating the effectiveness and toxicity of drugs. The method is stable, simple, and rapid for determining the expression of DMEs in animals." @default.
• W2598049088 created "2017-04-07" @default.
• W2598049088 creator A5001266118 @default.
• W2598049088 creator A5018863416 @default.
• W2598049088 creator A5028343982 @default.
• W2598049088 creator A5029539712 @default.
• W2598049088 creator A5030714205 @default.
• W2598049088 creator A5034776433 @default.
• W2598049088 creator A5045770872 @default.
• W2598049088 creator A5048227001 @default.
• W2598049088 creator A5052873728 @default.
• W2598049088 creator A5057255568 @default.
• W2598049088 creator A5059760738 @default.
• W2598049088 creator A5063343992 @default.
• W2598049088 creator A5066642665 @default.
• W2598049088 creator A5089079624 @default.
• W2598049088 date "2017-03-29" @default.
• W2598049088 modified "2023-10-07" @default.
• W2598049088 title "High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences" @default.
• W2598049088 cites W1621363655 @default.
• W2598049088 cites W1833612187 @default.
• W2598049088 cites W1964804210 @default.
• W2598049088 cites W1973215369 @default.
• W2598049088 cites W1977898022 @default.
• W2598049088 cites W1983176181 @default.
• W2598049088 cites W2001646009 @default.
• W2598049088 cites W2002417408 @default.
• W2598049088 cites W2004355922 @default.
• W2598049088 cites W2016623506 @default.
• W2598049088 cites W2021506453 @default.
• W2598049088 cites W2028874792 @default.
• W2598049088 cites W2040611122 @default.
• W2598049088 cites W2045597619 @default.
• W2598049088 cites W2060798530 @default.
• W2598049088 cites W2063977739 @default.
• W2598049088 cites W2064031078 @default.
• W2598049088 cites W2074701706 @default.
• W2598049088 cites W2084995916 @default.
• W2598049088 cites W2094003127 @default.
• W2598049088 cites W2098563159 @default.
• W2598049088 cites W2102626686 @default.
• W2598049088 cites W2113133140 @default.
• W2598049088 cites W2120624849 @default.
• W2598049088 cites W2151120582 @default.
• W2598049088 cites W2155462152 @default.
• W2598049088 cites W2159475701 @default.
• W2598049088 cites W2165074940 @default.
• W2598049088 cites W2198279851 @default.
• W2598049088 cites W2319946012 @default.
• W2598049088 cites W2327833596 @default.
• W2598049088 doi "https://doi.org/10.1124/dmd.116.074682" @default.
• W2598049088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28356314" @default.
• W2598049088 hasPublicationYear "2017" @default.
• W2598049088 type Work @default.
• W2598049088 sameAs 2598049088 @default.
• W2598049088 citedByCount "8" @default.
• W2598049088 countsByYear W25980490882017 @default.
• W2598049088 countsByYear W25980490882018 @default.
• W2598049088 countsByYear W25980490882019 @default.
• W2598049088 countsByYear W25980490882020 @default.
• W2598049088 countsByYear W25980490882022 @default.
• W2598049088 countsByYear W25980490882023 @default.
• W2598049088 crossrefType "journal-article" @default.
• W2598049088 hasAuthorship W2598049088A5001266118 @default.
• W2598049088 hasAuthorship W2598049088A5018863416 @default.
• W2598049088 hasAuthorship W2598049088A5028343982 @default.
• W2598049088 hasAuthorship W2598049088A5029539712 @default.
• W2598049088 hasAuthorship W2598049088A5030714205 @default.
• W2598049088 hasAuthorship W2598049088A5034776433 @default.
• W2598049088 hasAuthorship W2598049088A5045770872 @default.
• W2598049088 hasAuthorship W2598049088A5048227001 @default.
• W2598049088 hasAuthorship W2598049088A5052873728 @default.
• W2598049088 hasAuthorship W2598049088A5057255568 @default.
• W2598049088 hasAuthorship W2598049088A5059760738 @default.
• W2598049088 hasAuthorship W2598049088A5063343992 @default.
• W2598049088 hasAuthorship W2598049088A5066642665 @default.
• W2598049088 hasAuthorship W2598049088A5089079624 @default.
• W2598049088 hasBestOaLocation W25980490881 @default.
• W2598049088 hasConcept C109650736 @default.
• W2598049088 hasConcept C140027455 @default.
• W2598049088 hasConcept C162356407 @default.
• W2598049088 hasConcept C181199279 @default.
• W2598049088 hasConcept C185592680 @default.
• W2598049088 hasConcept C31827203 @default.
• W2598049088 hasConcept C43617362 @default.
• W2598049088 hasConcept C526171541 @default.
• W2598049088 hasConcept C55493867 @default.
• W2598049088 hasConcept C64489805 @default.
• W2598049088 hasConcept C86745063 @default.
• W2598049088 hasConcept C86803240 @default.
• W2598049088 hasConcept C98274493 @default.
• W2598049088 hasConceptScore W2598049088C109650736 @default.
• W2598049088 hasConceptScore W2598049088C140027455 @default.
• W2598049088 hasConceptScore W2598049088C162356407 @default.
• W2598049088 hasConceptScore W2598049088C181199279 @default.
• W2598049088 hasConceptScore W2598049088C185592680 @default.
• W2598049088 hasConceptScore W2598049088C31827203 @default.
• W2598049088 hasConceptScore W2598049088C43617362 @default.

• next