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• W2598092333 abstract "e19554 Background: Idelalisib, a selective oral inhibitor of PI3Kδ, demonstrated considerable anti-tumor activity in patients with relapsed/refractory iNHL in a phase 2 trial (Gopal, 2014). The purpose of this analysis was to evaluate patient-reported outcomes (PRO) data to determine whether drug treatment was associated with a change in health-related quality of life (HRQL). Methods: Eligible iNHL patients (pts) were refractory to both rituximab and an alkylating agent. Idelalisib 150 mg PO BID was administered continuously until disease progression. HRQL was measured by the 42-item Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym), comprising FACT-G subscales: Physical Well-being (PWB), Social/Family Well-being (SWB), Emotional Well-being (EWB), Functional Well-being (FWB), and the Lymphoma Subscale (LymS). Trial Outcome Index (TOI) is PWB + FWB + LymS. Higher scores reflect better HRQL. Minimally important differences (MID) on the FACT-G ranged 3-7 points (2-5 points for subscales). The FACT-..." @default.
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• W2598092333 date "2014-05-20" @default.
• W2598092333 modified "2023-10-02" @default.
• W2598092333 title "Patient-reported outcomes data from a phase 2 study of idelalisib in patients with refractory indolent B-cell non-Hodgkin lymphoma (iNHL)." @default.
• W2598092333 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e19554" @default.
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