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- W2598221358 endingPage "e0173981" @default.
- W2598221358 startingPage "e0173981" @default.
- W2598221358 abstract "We investigated IL-1-induced regulation of genes related to inflammation and atherogenesis in human keratinocytes and endothelial cells, and if 'diacerein', an oral IL-1 inhibiting drug currently approved for use in osteoarthritis, would reverse IL-1's effects on these cells. Primary human keratinocytes and coronary artery endothelial cells were treated with either IL-1α or IL-1β, with and without diacerein. Using PCR-array, we assessed differential gene-expression regulated by IL-1 and diacerein. We identified 34 pro-atherogenic genes in endothelial cells and 68 pro-inflammatory genes in keratinocytes significantly (p<0.05) regulated at least 2-fold by IL-1, in comparison to control. Diacerein completely or partially reversed this regulation on almost all genes. Using ELISA, we confirmed diacerein's ability to reverse IL-1-driven gene-regulation of 11 selected factors, at the protein level. The results support a novel idea that diacerein acts as an inhibitor of the pro-atherogenic and pro-inflammatory effects of IL-1. Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis. Further investigation into diacerein's effect on skin inflammation, atherogenesis and cardiovascular risk in animal models or humans is warranted." @default.
- W2598221358 created "2017-04-07" @default.
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- W2598221358 date "2017-03-21" @default.
- W2598221358 modified "2023-10-14" @default.
- W2598221358 title "Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells" @default.
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- W2598221358 doi "https://doi.org/10.1371/journal.pone.0173981" @default.
- W2598221358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5360272" @default.
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- W2598221358 hasPublicationYear "2017" @default.
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