FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2598352533> ?p ?o ?g. }

• W2598352533 endingPage "87" @default.
• W2598352533 startingPage "87" @default.
• W2598352533 abstract "Marine sponges contain a variety of low-molecular-weight compounds including guanidine alkaloids possessing different biological activities. Monanchomycalin B and urupocidin A were isolated from the marine sponge Monanchora pulchra. We found that they act as inhibitors of the TRPV1, TRPV2, and TRPV3 channels, but are inactive against the TRPA1 receptor. Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 μM for TRPV1, TRPV2, and TRPV3, correspondingly). Moreover, monanchomycalin B and urupocidin A are the first samples of marine alkaloids affecting the TRPV2 receptor. Two semi-synthetic urupocidin A derivatives were also obtained and tested against TRP (Transient Receptor Potential) receptors that allowed us to collect some data concerning the structure-activity relationship in this series of compounds. We showed that the removal of one of three side chains or double bonds in the other side chains in urupocidin A led to a decrease of the inhibitory activities. New ligands specific to the TRPV subfamily may be useful for the design of medicines as in the study of TRP channels biology." @default.
• W2598352533 created "2017-04-07" @default.
• W2598352533 creator A5003528434 @default.
• W2598352533 creator A5003947919 @default.
• W2598352533 creator A5014030117 @default.
• W2598352533 creator A5015502538 @default.
• W2598352533 creator A5025126499 @default.
• W2598352533 creator A5029160863 @default.
• W2598352533 creator A5049378616 @default.
• W2598352533 creator A5070248716 @default.
• W2598352533 creator A5075713249 @default.
• W2598352533 creator A5083515325 @default.
• W2598352533 date "2017-03-23" @default.
• W2598352533 modified "2023-10-15" @default.
• W2598352533 title "Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors" @default.
• W2598352533 cites W149310652 @default.
• W2598352533 cites W1570436054 @default.
• W2598352533 cites W1571837352 @default.
• W2598352533 cites W1626494010 @default.
• W2598352533 cites W1965695198 @default.
• W2598352533 cites W1982043650 @default.
• W2598352533 cites W1986519853 @default.
• W2598352533 cites W1988904945 @default.
• W2598352533 cites W2006599513 @default.
• W2598352533 cites W2007062738 @default.
• W2598352533 cites W2022026109 @default.
• W2598352533 cites W2034637337 @default.
• W2598352533 cites W2043651762 @default.
• W2598352533 cites W2053994239 @default.
• W2598352533 cites W2058145506 @default.
• W2598352533 cites W2071964380 @default.
• W2598352533 cites W2084370287 @default.
• W2598352533 cites W2101712329 @default.
• W2598352533 cites W2102394193 @default.
• W2598352533 cites W2111139603 @default.
• W2598352533 cites W2120512237 @default.
• W2598352533 cites W2122071004 @default.
• W2598352533 cites W2132336804 @default.
• W2598352533 cites W2144137612 @default.
• W2598352533 cites W2197101126 @default.
• W2598352533 cites W2331786114 @default.
• W2598352533 cites W2341598415 @default.
• W2598352533 cites W2399526708 @default.
• W2598352533 cites W2413704093 @default.
• W2598352533 cites W2468092910 @default.
• W2598352533 cites W2474538812 @default.
• W2598352533 cites W40623430 @default.
• W2598352533 cites W4211063687 @default.
• W2598352533 cites W4211129675 @default.
• W2598352533 cites W4256378143 @default.
• W2598352533 doi "https://doi.org/10.3390/md15040087" @default.
• W2598352533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5408233" @default.
• W2598352533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28333079" @default.
• W2598352533 hasPublicationYear "2017" @default.
• W2598352533 type Work @default.
• W2598352533 sameAs 2598352533 @default.
• W2598352533 citedByCount "19" @default.
• W2598352533 countsByYear W25983525332017 @default.
• W2598352533 countsByYear W25983525332018 @default.
• W2598352533 countsByYear W25983525332019 @default.
• W2598352533 countsByYear W25983525332020 @default.
• W2598352533 countsByYear W25983525332021 @default.
• W2598352533 countsByYear W25983525332022 @default.
• W2598352533 countsByYear W25983525332023 @default.
• W2598352533 crossrefType "journal-article" @default.
• W2598352533 hasAuthorship W2598352533A5003528434 @default.
• W2598352533 hasAuthorship W2598352533A5003947919 @default.
• W2598352533 hasAuthorship W2598352533A5014030117 @default.
• W2598352533 hasAuthorship W2598352533A5015502538 @default.
• W2598352533 hasAuthorship W2598352533A5025126499 @default.
• W2598352533 hasAuthorship W2598352533A5029160863 @default.
• W2598352533 hasAuthorship W2598352533A5049378616 @default.
• W2598352533 hasAuthorship W2598352533A5070248716 @default.
• W2598352533 hasAuthorship W2598352533A5075713249 @default.
• W2598352533 hasAuthorship W2598352533A5083515325 @default.
• W2598352533 hasBestOaLocation W25983525331 @default.
• W2598352533 hasConcept C104317684 @default.
• W2598352533 hasConcept C135285700 @default.
• W2598352533 hasConcept C155164980 @default.
• W2598352533 hasConcept C160145004 @default.
• W2598352533 hasConcept C170493617 @default.
• W2598352533 hasConcept C185592680 @default.
• W2598352533 hasConcept C2779463914 @default.
• W2598352533 hasConcept C50929876 @default.
• W2598352533 hasConcept C55493867 @default.
• W2598352533 hasConcept C71240020 @default.
• W2598352533 hasConcept C87649029 @default.
• W2598352533 hasConceptScore W2598352533C104317684 @default.
• W2598352533 hasConceptScore W2598352533C135285700 @default.
• W2598352533 hasConceptScore W2598352533C155164980 @default.
• W2598352533 hasConceptScore W2598352533C160145004 @default.
• W2598352533 hasConceptScore W2598352533C170493617 @default.
• W2598352533 hasConceptScore W2598352533C185592680 @default.
• W2598352533 hasConceptScore W2598352533C2779463914 @default.
• W2598352533 hasConceptScore W2598352533C50929876 @default.
• W2598352533 hasConceptScore W2598352533C55493867 @default.
• W2598352533 hasConceptScore W2598352533C71240020 @default.
• W2598352533 hasConceptScore W2598352533C87649029 @default.

• next