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• W2598478656 abstract "Endothelial progenitor cells (EPCs) derived from bone marrow and blood can differentiate into endothelial cells and promote neovascularization. In addition, EPCs are a promising cell source for the repair of various types of vascularized tissues and have been used in animal experiments and clinical trials for tissue repair. In this review, we focused on the kinetics of endogenous EPCs during tissue repair and the application of EPCs or stem cell populations containing EPCs for tissue regeneration in musculoskeletal and neural tissues including the bone, skeletal muscle, ligaments, spinal cord, and peripheral nerves. EPCs can be mobilized from bone marrow and recruited to injured tissue to contribute to neovascularization and tissue repair. In addition, EPCs or stem cell populations containing EPCs promote neovascularization and tissue repair through their differentiation to endothelial cells or tissue-specific cells, the upregulation of growth factors, and the induction and activation of endogenous stem cells. Human peripheral blood CD34(+) cells containing EPCs have been used in clinical trials of bone repair. Thus, EPCs are a promising cell source for the treatment of musculoskeletal and neural tissue injury." @default.
• W2598478656 created "2017-04-07" @default.
• W2598478656 creator A5029011338 @default.
• W2598478656 creator A5035568766 @default.
• W2598478656 creator A5070769533 @default.
• W2598478656 date "2017-01-01" @default.
• W2598478656 modified "2023-10-18" @default.
• W2598478656 title "The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues" @default.
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• W2598478656 doi "https://doi.org/10.1155/2017/1960804" @default.
• W2598478656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5387841" @default.
• W2598478656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28458693" @default.

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