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- W2598497561 abstract "Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules—DMSO and DMF—is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions." @default.
- W2598497561 created "2017-04-07" @default.
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- W2598497561 creator A5084308898 @default.
- W2598497561 date "2017-03-29" @default.
- W2598497561 modified "2023-09-23" @default.
- W2598497561 title "First Evidence of Polymorphism in Furosemide Solvates" @default.
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- W2598497561 doi "https://doi.org/10.1021/acs.cgd.6b01191" @default.
- W2598497561 hasPublicationYear "2017" @default.
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