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• W2598521174 abstract "Neurodegenerative diseases are often complicated by psychological and behavioural disturbances. Alzheimer’s disease is not free from such psychiatric complications. Alzheimer’s disease is most frequently the cause of dementia, and the prevalence and incidence of depressive symptoms are high. The prevalence is 40%, half of which are clinically significant and require treatment. When these depressive symptoms occur, they are often associated with other behavioural disturbances such as anxiety, irritability, delusions or apathy. Antidepressants are widely used in Alzheimer’s disease, and they are still prescribed primarily for the management of affective disorders, even though they may be effective in other psychological and behavioural problems. Longitudinal study design and survival analysis are rare. These studies identified functional decline, sleep disturbances and confrontational and aggressive behaviours as the principal predictors of the onset of depressive symptoms in Alzheimer’s disease. These findings confirm that it is important to look for psychiatric symptoms such as depression when non-specific behavioural disturbances such as confrontation or aggressiveness occur. Neuropsychiatric symptoms during the development of neurodegenerative diseases, and of Alzheimer’s disease in particular, offer an exciting area of research. We should consider the biological C. Arbus (*) Laboratoire du stress traumatique (LST) EA 4560, universite de Toulouse, UPS, hopital Casselardit, 170, avenue de Casselardit, TSA 40031, F-31059 Toulouse cedex 09, France e-mail : arbus.c@chu-toulouse.fr Service universitaire de psychiatrie, CHU de Toulouse, F-31000 Toulouse, France V. Camus UMR Inserm U930 & CNRS ERL 3106, universite Francois-Rabelais, F-37000 Tours, France Clinique psychiatrique universitaire, CHRU de Tours, F-37044 Tours cedex 09, France Cah. Annee Gerontol. (2011) 3:107-118 DOI 10.1007/s12612-011-0187-4" @default.
• W2598521174 created "2017-04-07" @default.
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• W2598521174 date "2011-01-01" @default.
• W2598521174 modified "2023-09-24" @default.
• W2598521174 title "Les symptômes dépressifs de la maladie d’Alzheimer : trouble affectif Depressive symptoms in Alzheimer’s disease: a neuropsychiatric affective disorder" @default.
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