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- W2598532180 abstract "Tofacitinib is a synthetic targeted disease modifying antirheumatic drug (DMARD), which has demonstrated safety and efficacy in multiple randomized, double-blind, controlled clinical trials, in different settings, for the treatment of moderate to severe rheumatoid arthritis (RA). Is the first drug of this type to be approved for the treatment of RA and its mechanism of action is exerted through inhibition of the enzyme Janus kinases (JAK), which mediate signal transmission to the intracellular environment of multiple cytokine receptors involved in the immune and inflammatory response. Tofacitinib has been approved in Argentina in september 2013, providing already important experience in clinical aspects and pharmacovigilance in patients of real life in this country. The aim of this paper is to present 2 clinical cases of tofacitinib use in daily clinical practice, which may be representative of common clinical scenarios." @default.
- W2598532180 created "2017-04-07" @default.
- W2598532180 creator A5023546634 @default.
- W2598532180 date "2016-03-04" @default.
- W2598532180 modified "2023-09-23" @default.
- W2598532180 title "Experiencia clínica con tofacitinib en la práctica diaria: descripción de dos casos" @default.
- W2598532180 hasPublicationYear "2016" @default.
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