FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2598857650> ?p ?o ?g. }

• W2598857650 endingPage "27" @default.
• W2598857650 startingPage "22" @default.
• W2598857650 abstract "Increasing evidence indicate that the Krüppel-like factor KLF15, a member of Cys2/His2 zinc-finger DNA-binding proteins, attenuates cardiac hypertrophy. However, the role of KLF15 in cardiovascular system is largely unknown and the exact molecular mechanism of its protective function is not fully elucidated. In the present study, we established a mouse model of cardiac hypertrophy and found that KLF15 expression was down-regulated in hypertrophic hearts. To evaluate the roles of KLF15 in cardiac hypertrophy, we generated transgenic mice overexpressing KLF15 of KLF15 knockdown mice and subsequently induced cardiac hypertrophy. The results indicated that KLF15 overexpression protects mice from ISO-induced cardiac hypertrophy, with reduced ratios of heart weight (HW)/body weight (BW) and cross-sectional area. We also observed that KLF15 overexpression attenuated cardiac fibrosis, inhibited apoptosis and induced autophagy in cardiomyocytes compared with KLF15 knockdown mice. More importantly, we found that the KLF15 overexpression inhibited the Akt/mTOR signaling pathway. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases." @default.
• W2598857650 created "2017-04-07" @default.
• W2598857650 creator A5006354151 @default.
• W2598857650 creator A5014209509 @default.
• W2598857650 creator A5052491265 @default.
• W2598857650 creator A5052498846 @default.
• W2598857650 creator A5067981145 @default.
• W2598857650 date "2017-05-01" @default.
• W2598857650 modified "2023-10-13" @default.
• W2598857650 title "KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling" @default.
• W2598857650 cites W1497826694 @default.
• W2598857650 cites W1870167959 @default.
• W2598857650 cites W1881447828 @default.
• W2598857650 cites W1964516710 @default.
• W2598857650 cites W1965494606 @default.
• W2598857650 cites W1967229720 @default.
• W2598857650 cites W1989173460 @default.
• W2598857650 cites W2009621905 @default.
• W2598857650 cites W2025373703 @default.
• W2598857650 cites W2037216032 @default.
• W2598857650 cites W2053936366 @default.
• W2598857650 cites W2055351499 @default.
• W2598857650 cites W2075334729 @default.
• W2598857650 cites W2115339387 @default.
• W2598857650 cites W2149250742 @default.
• W2598857650 cites W2152879697 @default.
• W2598857650 cites W2153913348 @default.
• W2598857650 cites W2156941071 @default.
• W2598857650 cites W2164624059 @default.
• W2598857650 cites W2236890339 @default.
• W2598857650 cites W2338882743 @default.
• W2598857650 cites W2474901046 @default.
• W2598857650 cites W2527864505 @default.
• W2598857650 cites W2556569686 @default.
• W2598857650 cites W28613156 @default.
• W2598857650 doi "https://doi.org/10.1016/j.bbrc.2017.03.087" @default.
• W2598857650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28336438" @default.
• W2598857650 hasPublicationYear "2017" @default.
• W2598857650 type Work @default.
• W2598857650 sameAs 2598857650 @default.
• W2598857650 citedByCount "16" @default.
• W2598857650 countsByYear W25988576502017 @default.
• W2598857650 countsByYear W25988576502018 @default.
• W2598857650 countsByYear W25988576502019 @default.
• W2598857650 countsByYear W25988576502020 @default.
• W2598857650 countsByYear W25988576502021 @default.
• W2598857650 countsByYear W25988576502022 @default.
• W2598857650 countsByYear W25988576502023 @default.
• W2598857650 crossrefType "journal-article" @default.
• W2598857650 hasAuthorship W2598857650A5006354151 @default.
• W2598857650 hasAuthorship W2598857650A5014209509 @default.
• W2598857650 hasAuthorship W2598857650A5052491265 @default.
• W2598857650 hasAuthorship W2598857650A5052498846 @default.
• W2598857650 hasAuthorship W2598857650A5067981145 @default.
• W2598857650 hasConcept C111566952 @default.
• W2598857650 hasConcept C126322002 @default.
• W2598857650 hasConcept C134018914 @default.
• W2598857650 hasConcept C167414201 @default.
• W2598857650 hasConcept C173396325 @default.
• W2598857650 hasConcept C190283241 @default.
• W2598857650 hasConcept C203522944 @default.
• W2598857650 hasConcept C2778198053 @default.
• W2598857650 hasConcept C55493867 @default.
• W2598857650 hasConcept C62478195 @default.
• W2598857650 hasConcept C71924100 @default.
• W2598857650 hasConcept C75217442 @default.
• W2598857650 hasConcept C86554907 @default.
• W2598857650 hasConcept C86803240 @default.
• W2598857650 hasConcept C95444343 @default.
• W2598857650 hasConcept C98274493 @default.
• W2598857650 hasConceptScore W2598857650C111566952 @default.
• W2598857650 hasConceptScore W2598857650C126322002 @default.
• W2598857650 hasConceptScore W2598857650C134018914 @default.
• W2598857650 hasConceptScore W2598857650C167414201 @default.
• W2598857650 hasConceptScore W2598857650C173396325 @default.
• W2598857650 hasConceptScore W2598857650C190283241 @default.
• W2598857650 hasConceptScore W2598857650C203522944 @default.
• W2598857650 hasConceptScore W2598857650C2778198053 @default.
• W2598857650 hasConceptScore W2598857650C55493867 @default.
• W2598857650 hasConceptScore W2598857650C62478195 @default.
• W2598857650 hasConceptScore W2598857650C71924100 @default.
• W2598857650 hasConceptScore W2598857650C75217442 @default.
• W2598857650 hasConceptScore W2598857650C86554907 @default.
• W2598857650 hasConceptScore W2598857650C86803240 @default.
• W2598857650 hasConceptScore W2598857650C95444343 @default.
• W2598857650 hasConceptScore W2598857650C98274493 @default.
• W2598857650 hasIssue "1" @default.
• W2598857650 hasLocation W25988576501 @default.
• W2598857650 hasLocation W25988576502 @default.
• W2598857650 hasOpenAccess W2598857650 @default.
• W2598857650 hasPrimaryLocation W25988576501 @default.
• W2598857650 hasRelatedWork W2024933597 @default.
• W2598857650 hasRelatedWork W2070783513 @default.
• W2598857650 hasRelatedWork W2098584395 @default.
• W2598857650 hasRelatedWork W2422815049 @default.
• W2598857650 hasRelatedWork W2916964185 @default.
• W2598857650 hasRelatedWork W2982360817 @default.
• W2598857650 hasRelatedWork W3116479654 @default.

• next