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- W2598879757 abstract "In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies. Highly specialized antibodies derived from rabbits could transform our ability to detect and treat diseases such as cancer and HIV. Christoph Rader and co-workers at The Scripps Research Institute in Florida, USA, reviewed the use of rabbit antibodies in research, diagnostics and therapy. Rabbits are commonly used as models in immunology because of their highly sensitive immune system, which generates large numbers of antibodies in response to multiple antigens. Rabbit polyclonal antibodies, antibodies that target different ‘epitopes’ (or sites) on an antigen molecule, are used to prevent and treat transplant rejection. Rader's team highlights the outstanding performance in pre-clinical studies of novel rabbit monoclonal antibodies (mAbs), highly specialised antibodies that target single epitopes. Among many potential applications, rabbit mAbs can detect and destroy cancer cells, and may aid in developing vaccines for diseases like HIV." @default.
- W2598879757 created "2017-04-07" @default.
- W2598879757 creator A5065812703 @default.
- W2598879757 creator A5071637005 @default.
- W2598879757 creator A5088287990 @default.
- W2598879757 date "2017-03-24" @default.
- W2598879757 modified "2023-10-16" @default.
- W2598879757 title "From rabbit antibody repertoires to rabbit monoclonal antibodies" @default.
- W2598879757 cites W101054436 @default.
- W2598879757 cites W109035179 @default.
- W2598879757 cites W1482686282 @default.
- W2598879757 cites W1494602561 @default.
- W2598879757 cites W1498617908 @default.
- W2598879757 cites W1508914855 @default.
- W2598879757 cites W1511587230 @default.
- W2598879757 cites W1542142855 @default.
- W2598879757 cites W1549906047 @default.
- W2598879757 cites W1556577452 @default.
- W2598879757 cites W1558863076 @default.
- W2598879757 cites W1561655392 @default.
- W2598879757 cites W1568186032 @default.
- W2598879757 cites W162122412 @default.
- W2598879757 cites W1649248250 @default.
- W2598879757 cites W1657952695 @default.
- W2598879757 cites W1661961827 @default.
- W2598879757 cites W170103237 @default.
- W2598879757 cites W1713285949 @default.
- W2598879757 cites W1758612015 @default.
- W2598879757 cites W1821277371 @default.
- W2598879757 cites W1854161039 @default.
- W2598879757 cites W1884779989 @default.
- W2598879757 cites W1907111337 @default.
- W2598879757 cites W1925878530 @default.
- W2598879757 cites W1930762737 @default.
- W2598879757 cites W1931511147 @default.
- W2598879757 cites W1964187194 @default.
- W2598879757 cites W1965498936 @default.
- W2598879757 cites W1965878517 @default.
- W2598879757 cites W1966427975 @default.
- W2598879757 cites W1967343996 @default.
- W2598879757 cites W1967657016 @default.
- W2598879757 cites W1969447936 @default.
- W2598879757 cites W1969650153 @default.
- W2598879757 cites W1969689981 @default.
- W2598879757 cites W1970818121 @default.
- W2598879757 cites W1971242419 @default.
- W2598879757 cites W1972263794 @default.
- W2598879757 cites W1976156218 @default.
- W2598879757 cites W1977111277 @default.
- W2598879757 cites W1977273002 @default.
- W2598879757 cites W1977378497 @default.
- W2598879757 cites W1980193228 @default.
- W2598879757 cites W1981120510 @default.
- W2598879757 cites W1982073152 @default.
- W2598879757 cites W1982432247 @default.
- W2598879757 cites W1982712272 @default.
- W2598879757 cites W1983494459 @default.
- W2598879757 cites W1985154098 @default.
- W2598879757 cites W1985997318 @default.
- W2598879757 cites W1986788877 @default.
- W2598879757 cites W1987534225 @default.
- W2598879757 cites W1990210813 @default.
- W2598879757 cites W1990300139 @default.
- W2598879757 cites W1991555803 @default.
- W2598879757 cites W1992521297 @default.
- W2598879757 cites W1993236072 @default.
- W2598879757 cites W1993377729 @default.
- W2598879757 cites W1993575340 @default.
- W2598879757 cites W1993928780 @default.
- W2598879757 cites W1997655235 @default.
- W2598879757 cites W1998213703 @default.
- W2598879757 cites W2000387754 @default.
- W2598879757 cites W2002609071 @default.
- W2598879757 cites W2002774751 @default.
- W2598879757 cites W2003391115 @default.
- W2598879757 cites W2004694928 @default.
- W2598879757 cites W2006189801 @default.
- W2598879757 cites W2007069748 @default.
- W2598879757 cites W2007202358 @default.
- W2598879757 cites W2007892928 @default.
- W2598879757 cites W2008826234 @default.
- W2598879757 cites W2008992691 @default.
- W2598879757 cites W2009695842 @default.
- W2598879757 cites W2009811887 @default.
- W2598879757 cites W2009962689 @default.
- W2598879757 cites W2011412980 @default.
- W2598879757 cites W2015388675 @default.
- W2598879757 cites W2016837737 @default.
- W2598879757 cites W2016946888 @default.
- W2598879757 cites W2022486114 @default.
- W2598879757 cites W2024170221 @default.
- W2598879757 cites W2025640975 @default.
- W2598879757 cites W2026981847 @default.
- W2598879757 cites W2027425640 @default.
- W2598879757 cites W2027812727 @default.
- W2598879757 cites W2028450449 @default.
- W2598879757 cites W2030522563 @default.
- W2598879757 cites W2032962654 @default.