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- W2598909327 abstract "Most of existing techniques cannot be used to detect molecular biomarkers (i.e., protein and DNA) contained in complex body fluids due to issues such as enzyme inhibition or signal interference. This thesis describes a nanoparticle-based thermal detection method for the highly sensitive detections of multiple DNA biomarkers or proteins contained in different type of fluids such as buffer solution, cell lysate and milk by using solid-liquid phase change nanoparticles as thermal barcodes. Besides, this method has also been applied for thrombin detection by using RNA aptamer-functionalized phase change nanoparticles as thermal probes. Furthermore, using nanostructured Si surface that have higher specific area can enhance the detection sensitivity by four times compared to use flat aluminum surfaces. The detection is based on the principle that the temperature of solid will not rise above its melting temperature unless all solid is molten, thus nanoparticles will have sharp melting peak during a linear thermal scan process. A one-to-one correspondence can be created between one type of nanoparticles and one type of biomarker, and multiple biomarkers can be detected simultaneously using different type nanoparticles. The melting temperature and the heat flow reflect the type and the concentration of biomarker, respectively. The melting temperatures of nanoparticles are designed to be over 100°C to avoid interference from species contained in fluids. The use of thermal nanoparticles allows detection of multiple low concentration DNAs or proteins in a complex fluid such as cell lysate regardless of the color, salt concentration, and conductivity of the sample." @default.
- W2598909327 created "2017-04-07" @default.
- W2598909327 creator A5040107793 @default.
- W2598909327 date "2010-01-01" @default.
- W2598909327 modified "2023-09-28" @default.
- W2598909327 title "Thermal Detection Of Biomarkers Using Phase Change Nanoparticles" @default.
- W2598909327 cites W1512509057 @default.
- W2598909327 cites W1547745058 @default.
- W2598909327 cites W1561712812 @default.
- W2598909327 cites W184238969 @default.
- W2598909327 cites W1875933026 @default.
- W2598909327 cites W1964951606 @default.
- W2598909327 cites W1968566387 @default.
- W2598909327 cites W1972790909 @default.
- W2598909327 cites W1975034066 @default.
- W2598909327 cites W1976121079 @default.
- W2598909327 cites W1976431927 @default.
- W2598909327 cites W1979260070 @default.
- W2598909327 cites W1981089252 @default.
- W2598909327 cites W1985608242 @default.
- W2598909327 cites W1986107627 @default.
- W2598909327 cites W1986258679 @default.
- W2598909327 cites W1987888470 @default.
- W2598909327 cites W1988175809 @default.
- W2598909327 cites W1989946791 @default.
- W2598909327 cites W1990662490 @default.
- W2598909327 cites W1991761596 @default.
- W2598909327 cites W1994052747 @default.
- W2598909327 cites W1999434366 @default.
- W2598909327 cites W1999883774 @default.
- W2598909327 cites W1999951470 @default.
- W2598909327 cites W2001174441 @default.
- W2598909327 cites W2001576176 @default.
- W2598909327 cites W2003097416 @default.
- W2598909327 cites W2004787483 @default.
- W2598909327 cites W2005134172 @default.
- W2598909327 cites W2006058395 @default.
- W2598909327 cites W2006402809 @default.
- W2598909327 cites W2006882472 @default.
- W2598909327 cites W2006920668 @default.
- W2598909327 cites W2007644079 @default.
- W2598909327 cites W2009368567 @default.
- W2598909327 cites W2011254473 @default.
- W2598909327 cites W2012040964 @default.
- W2598909327 cites W2013113223 @default.
- W2598909327 cites W2014123049 @default.
- W2598909327 cites W2014434454 @default.
- W2598909327 cites W2014482505 @default.
- W2598909327 cites W2014773436 @default.
- W2598909327 cites W2016754833 @default.
- W2598909327 cites W2017079536 @default.
- W2598909327 cites W2020343586 @default.
- W2598909327 cites W2022472252 @default.
- W2598909327 cites W2024230043 @default.
- W2598909327 cites W2024310259 @default.
- W2598909327 cites W2024572952 @default.
- W2598909327 cites W2024726220 @default.
- W2598909327 cites W2026568991 @default.
- W2598909327 cites W2029184299 @default.
- W2598909327 cites W2032118018 @default.
- W2598909327 cites W2033010020 @default.
- W2598909327 cites W2033553988 @default.
- W2598909327 cites W2034269086 @default.
- W2598909327 cites W2034556388 @default.
- W2598909327 cites W2035170598 @default.
- W2598909327 cites W2036646476 @default.
- W2598909327 cites W2038637564 @default.
- W2598909327 cites W2039241972 @default.
- W2598909327 cites W2040653505 @default.
- W2598909327 cites W2045260427 @default.
- W2598909327 cites W2046427987 @default.
- W2598909327 cites W2046890107 @default.
- W2598909327 cites W2046975261 @default.
- W2598909327 cites W2048146515 @default.
- W2598909327 cites W2050031030 @default.
- W2598909327 cites W2050574264 @default.
- W2598909327 cites W2050717506 @default.
- W2598909327 cites W2051080992 @default.
- W2598909327 cites W2052273937 @default.
- W2598909327 cites W2052281981 @default.
- W2598909327 cites W2054409425 @default.
- W2598909327 cites W2058541035 @default.
- W2598909327 cites W2058781399 @default.
- W2598909327 cites W2061843780 @default.
- W2598909327 cites W2062485439 @default.
- W2598909327 cites W2071351222 @default.
- W2598909327 cites W2072592245 @default.
- W2598909327 cites W2075409469 @default.
- W2598909327 cites W2075622091 @default.
- W2598909327 cites W2075940721 @default.
- W2598909327 cites W2077338264 @default.
- W2598909327 cites W2078503321 @default.
- W2598909327 cites W2078820160 @default.
- W2598909327 cites W2079321730 @default.
- W2598909327 cites W2082454728 @default.
- W2598909327 cites W2085691644 @default.
- W2598909327 cites W2085864023 @default.
- W2598909327 cites W2086754387 @default.
- W2598909327 cites W2090405107 @default.
- W2598909327 cites W2091411866 @default.