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- W2599053467 abstract "Since the seminal finding almost 50 years ago that exercise training increases mitochondrial content in skeletal muscle, a considerable amount of research has been dedicated to elucidate the mechanisms inducing mitochondrial biogenesis. The discovery of peroxisome proliferator-activated receptor γ co-activator 1α as a major regulator of exercise-induced gene transcription was instrumental in beginning to understand the signals regulating this process. However, almost two decades after its discovery, our understanding of the signals inducing mitochondrial biogenesis remain poorly defined, limiting our insights into possible novel training modalities in elite athletes that can increase the oxidative potential of muscle. In particular, the role of mitochondrial reactive oxygen species has received very little attention; however, several lifestyle interventions associated with an increase in mitochondrial reactive oxygen species coincide with the induction of mitochondrial biogenesis. Furthermore, the diminishing returns of exercise training are associated with reductions in exercise-induced, mitochondrial-derived reactive oxygen species. Therefore, research focused on altering redox signaling in elite athletes may prove to be effective at inducing mitochondrial biogenesis and augmenting training regimes. In the context of exercise performance, the biological effect of increasing mitochondrial content is an attenuated rise in free cytosolic adenosine diphosphate (ADP), and subsequently decreased carbohydrate flux at a given power output. Recent evidence has shown that mitochondrial ADP sensitivity is a regulated process influenced by nutritional interventions, acute exercise, and exercise training. This knowledge raises the potential to improve mitochondrial bioenergetics in the absence of changes in mitochondrial content. Elucidating the mechanisms influencing the acute regulation of mitochondrial ADP sensitivity could have performance benefits in athletes, especially as these individuals display high levels of mitochondria, and therefore are subjects in whom it is notoriously difficult to further induce mitochondrial adaptations. In addition to changes in ADP sensitivity, an increase in mitochondrial coupling would have a similar bioenergetic response, namely a reduction in free cytosolic ADP. While classically the stoichiometry of the electron transport chain has been considered rigid, recent evidence suggests that sodium nitrate can improve the efficiency of this process, creating the potential for dietary sources of nitrate (e.g., beetroot juice) to display similar improvements in exercise performance. The current review focuses on these processes, while also discussing the biological relevance in the context of exercise performance." @default.
- W2599053467 created "2017-04-07" @default.
- W2599053467 creator A5018080866 @default.
- W2599053467 date "2017-03-01" @default.
- W2599053467 modified "2023-09-24" @default.
- W2599053467 title "Nutrition and Training Influences on the Regulation of Mitochondrial Adenosine Diphosphate Sensitivity and Bioenergetics" @default.
- W2599053467 cites W1135892919 @default.
- W2599053467 cites W1560087511 @default.
- W2599053467 cites W1566648241 @default.
- W2599053467 cites W1600059068 @default.
- W2599053467 cites W1615913434 @default.
- W2599053467 cites W1876608137 @default.
- W2599053467 cites W1895065960 @default.
- W2599053467 cites W1932131353 @default.
- W2599053467 cites W1942141121 @default.
- W2599053467 cites W1964694971 @default.
- W2599053467 cites W1964739304 @default.
- W2599053467 cites W1968112618 @default.
- W2599053467 cites W1972195273 @default.
- W2599053467 cites W1989305503 @default.
- W2599053467 cites W1993110160 @default.
- W2599053467 cites W1996946589 @default.
- W2599053467 cites W2000871049 @default.
- W2599053467 cites W2004691285 @default.
- W2599053467 cites W2005411902 @default.
- W2599053467 cites W2008632158 @default.
- W2599053467 cites W2008710537 @default.
- W2599053467 cites W2012135330 @default.
- W2599053467 cites W2015155743 @default.
- W2599053467 cites W2019241758 @default.
- W2599053467 cites W2058249580 @default.
- W2599053467 cites W2063936188 @default.
- W2599053467 cites W2069342809 @default.
- W2599053467 cites W2077645437 @default.
- W2599053467 cites W2078125648 @default.
- W2599053467 cites W2080782826 @default.
- W2599053467 cites W2086900431 @default.
- W2599053467 cites W2088262190 @default.
- W2599053467 cites W2090389306 @default.
- W2599053467 cites W2091902574 @default.
- W2599053467 cites W2092551351 @default.
- W2599053467 cites W2103982975 @default.
- W2599053467 cites W2105404724 @default.
- W2599053467 cites W2106643427 @default.
- W2599053467 cites W2107621770 @default.
- W2599053467 cites W2115176938 @default.
- W2599053467 cites W2117642435 @default.
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- W2599053467 cites W2127974247 @default.
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- W2599053467 cites W2136280068 @default.
- W2599053467 cites W2141050227 @default.
- W2599053467 cites W2141077548 @default.
- W2599053467 cites W2141578359 @default.
- W2599053467 cites W2145094126 @default.
- W2599053467 cites W2146776933 @default.
- W2599053467 cites W2147727052 @default.
- W2599053467 cites W2152101492 @default.
- W2599053467 cites W2152699606 @default.
- W2599053467 cites W2160524748 @default.
- W2599053467 cites W2161695921 @default.
- W2599053467 cites W2162033191 @default.
- W2599053467 cites W2162707945 @default.
- W2599053467 cites W2167120395 @default.
- W2599053467 cites W2167703406 @default.
- W2599053467 cites W2169996321 @default.
- W2599053467 cites W2170120009 @default.
- W2599053467 cites W2174795486 @default.
- W2599053467 cites W2260427912 @default.
- W2599053467 cites W2314015436 @default.
- W2599053467 cites W2322994506 @default.
- W2599053467 cites W2402820299 @default.
- W2599053467 cites W2410292096 @default.
- W2599053467 cites W2463802757 @default.
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- W2599053467 doi "https://doi.org/10.1007/s40279-017-0693-3" @default.
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