Matches in SemOpenAlex for { <https://semopenalex.org/work/W2599179905> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2599179905 abstract "Ginsenosides F4 and Rg6 (GF4 and GRg6), two main active components of steamed notoginseng or red ginseng, are dehydrated disaccharide saponins. In this work, biotransformation of ginsenosides F4 and Rg6 in zebrafish was investigated by qualitatively identifying their metabolites and then proposing their possible metabolic pathways. The prediction of possible metabolism of ginsenosides F4 and Rg6 using zebrafish model which can effectively simulate existing mammals model was early and quickly performed. Metabolites of ginsenosides F4 and Rg6 after exposing to zebrafish for 24 h were identified by Ultraperformance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry. A total of 8 and 6 metabolites of ginsenosides F4 and Rg6 were identified in zebrafish, respectively. Of these, 7 and 5, including M1, M3-M5, M7-M9 and N1 (N5), N2, N4 (N9), N7-N8 were reported for the first time as far as we know. The mechanisms of their biotransformation involved were further deduced to be desugarization, glucuronidation, sulfation, dehydroxylation, loss of C-17 and/or C-23 residue pathways. It was concluded that loss of rhamnose at position C-6 and glucuronidation at position C-3 in zebrafish were considered as the main physiologic and metabolic processes of ginsenosides F4 and ginsenosides Rg6, respectively." @default.
- W2599179905 created "2017-04-07" @default.
- W2599179905 creator A5001212769 @default.
- W2599179905 creator A5008637608 @default.
- W2599179905 creator A5012165505 @default.
- W2599179905 creator A5031307161 @default.
- W2599179905 creator A5034657959 @default.
- W2599179905 creator A5049539908 @default.
- W2599179905 creator A5049689249 @default.
- W2599179905 creator A5052743581 @default.
- W2599179905 creator A5088330985 @default.
- W2599179905 creator A5091068751 @default.
- W2599179905 date "2017-03-28" @default.
- W2599179905 modified "2023-09-27" @default.
- W2599179905 title "Biotransformation of ginsenosides F4 and Rg6 in zebrafish" @default.
- W2599179905 cites W1970931371 @default.
- W2599179905 cites W1978388208 @default.
- W2599179905 cites W1990578850 @default.
- W2599179905 cites W2008216426 @default.
- W2599179905 cites W2014640933 @default.
- W2599179905 cites W2024486195 @default.
- W2599179905 cites W2072320653 @default.
- W2599179905 cites W2093805061 @default.
- W2599179905 doi "https://doi.org/10.1080/10286020.2017.1307184" @default.
- W2599179905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28349702" @default.
- W2599179905 hasPublicationYear "2017" @default.
- W2599179905 type Work @default.
- W2599179905 sameAs 2599179905 @default.
- W2599179905 citedByCount "0" @default.
- W2599179905 crossrefType "journal-article" @default.
- W2599179905 hasAuthorship W2599179905A5001212769 @default.
- W2599179905 hasAuthorship W2599179905A5008637608 @default.
- W2599179905 hasAuthorship W2599179905A5012165505 @default.
- W2599179905 hasAuthorship W2599179905A5031307161 @default.
- W2599179905 hasAuthorship W2599179905A5034657959 @default.
- W2599179905 hasAuthorship W2599179905A5049539908 @default.
- W2599179905 hasAuthorship W2599179905A5049689249 @default.
- W2599179905 hasAuthorship W2599179905A5052743581 @default.
- W2599179905 hasAuthorship W2599179905A5088330985 @default.
- W2599179905 hasAuthorship W2599179905A5091068751 @default.
- W2599179905 hasConcept C104317684 @default.
- W2599179905 hasConcept C142724271 @default.
- W2599179905 hasConcept C155138218 @default.
- W2599179905 hasConcept C181199279 @default.
- W2599179905 hasConcept C185592680 @default.
- W2599179905 hasConcept C192989942 @default.
- W2599179905 hasConcept C204787440 @default.
- W2599179905 hasConcept C2776539398 @default.
- W2599179905 hasConcept C2776878037 @default.
- W2599179905 hasConcept C2777032962 @default.
- W2599179905 hasConcept C2778564307 @default.
- W2599179905 hasConcept C2779232237 @default.
- W2599179905 hasConcept C2779907587 @default.
- W2599179905 hasConcept C27881333 @default.
- W2599179905 hasConcept C43617362 @default.
- W2599179905 hasConcept C55493867 @default.
- W2599179905 hasConcept C62231903 @default.
- W2599179905 hasConcept C71924100 @default.
- W2599179905 hasConcept C87644729 @default.
- W2599179905 hasConceptScore W2599179905C104317684 @default.
- W2599179905 hasConceptScore W2599179905C142724271 @default.
- W2599179905 hasConceptScore W2599179905C155138218 @default.
- W2599179905 hasConceptScore W2599179905C181199279 @default.
- W2599179905 hasConceptScore W2599179905C185592680 @default.
- W2599179905 hasConceptScore W2599179905C192989942 @default.
- W2599179905 hasConceptScore W2599179905C204787440 @default.
- W2599179905 hasConceptScore W2599179905C2776539398 @default.
- W2599179905 hasConceptScore W2599179905C2776878037 @default.
- W2599179905 hasConceptScore W2599179905C2777032962 @default.
- W2599179905 hasConceptScore W2599179905C2778564307 @default.
- W2599179905 hasConceptScore W2599179905C2779232237 @default.
- W2599179905 hasConceptScore W2599179905C2779907587 @default.
- W2599179905 hasConceptScore W2599179905C27881333 @default.
- W2599179905 hasConceptScore W2599179905C43617362 @default.
- W2599179905 hasConceptScore W2599179905C55493867 @default.
- W2599179905 hasConceptScore W2599179905C62231903 @default.
- W2599179905 hasConceptScore W2599179905C71924100 @default.
- W2599179905 hasConceptScore W2599179905C87644729 @default.
- W2599179905 hasFunder F4320322769 @default.
- W2599179905 hasFunder F4320327502 @default.
- W2599179905 hasLocation W25991799051 @default.
- W2599179905 hasLocation W25991799052 @default.
- W2599179905 hasOpenAccess W2599179905 @default.
- W2599179905 hasPrimaryLocation W25991799051 @default.
- W2599179905 hasRelatedWork W1517581088 @default.
- W2599179905 hasRelatedWork W1975714310 @default.
- W2599179905 hasRelatedWork W1988532962 @default.
- W2599179905 hasRelatedWork W1996913578 @default.
- W2599179905 hasRelatedWork W2054064635 @default.
- W2599179905 hasRelatedWork W2056181105 @default.
- W2599179905 hasRelatedWork W2323022944 @default.
- W2599179905 hasRelatedWork W2361518483 @default.
- W2599179905 hasRelatedWork W2462401950 @default.
- W2599179905 hasRelatedWork W3214008846 @default.
- W2599179905 isParatext "false" @default.
- W2599179905 isRetracted "false" @default.
- W2599179905 magId "2599179905" @default.
- W2599179905 workType "article" @default.