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• W2599197112 startingPage "1150" @default.
• W2599197112 abstract "Smad ubiquitination regulatory factor 1 (Smurf1) is a HECT ‐type E3 ubiquitin ligase that regulates several important signaling pathways, including the bone morphogenetic protein pathway and the transforming growth factor‐beta ( TGF ‐β) signaling pathway. However, the function of Smurf1 in cell cycle progression remains unclear. Here, we demonstrate that silencing of Smurf1 results in S phase arrest, confirming that Smurf1 is required for S phase progression. Furthermore, we demonstrate that Smurf1‐mediated S phase progression is largely dependent on the ubiquitination‐dependent degradation of Wee1. This study defines a novel role for Smurf1 in controlling S phase progression by promoting Wee1 degradation." @default.
• W2599197112 created "2017-04-07" @default.
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• W2599197112 date "2017-04-01" @default.
• W2599197112 modified "2023-10-17" @default.
• W2599197112 title "Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation" @default.
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• W2599197112 doi "https://doi.org/10.1002/1873-3468.12624" @default.
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