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- W2599245395 abstract "N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells. In addition, caveolin-1 mediates the suppressive function of NDRG1 in epithelial-mesenchymal transition, migration and invasion in vitro and metastasis in vivo. These results help to fulfill the potential mechanisms of NDRG1 in anti-metastatic treatment for human colorectal cancer." @default.
- W2599245395 created "2017-04-07" @default.
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- W2599245395 date "2017-03-27" @default.
- W2599245395 modified "2023-10-17" @default.
- W2599245395 title "The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells" @default.
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- W2599245395 doi "https://doi.org/10.1038/onc.2017.74" @default.
- W2599245395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5537633" @default.
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