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• W2599490334 abstract "8046 Background: Selumetinib (AZD6244, ARRY-142886, S) is a potent inhibitor of MEK, with promising activity with docetaxel in pts with previously treated NSCLC. Non-clinical data suggest potential negative interaction with platin. We conducted a phase Ib study testing continuous or intermittent S with either cisplatin/pemetrexed (CPe; non-squamous) or carboplatin/paclitaxel (CPa) in previously untreated NSCLC. Methods: Pts received CPa (C AUC 6; Pa 200mg/ m2) or CPe (C 75mg/ m2 ; Pe 500mg/ m2) or for 4-6 21day cycles; single-agent S continued. A 3+ 3 design was used, dose levels (DL) were: DL1 50mg bid d2-19, DL2 75 mg bid d2-19, DL3 75 mg bid d1-21 (continuous) with an expansion cohort at RP2D. DLTs were assessed in cycle 1. Results: 30 pts were enrolled and 27 currently evaluable for adverse events (AE). In both cohorts, the most common S related toxicities were mild GI and skin. For CPa, 11 pts were treated, and no DLTs were seen at any DL. CPa related AEs were as expected. 2 pts had dose reductions o..." @default.
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• W2599490334 date "2015-05-20" @default.
• W2599490334 modified "2023-09-22" @default.
• W2599490334 title "A phase Ib study of selumetinib in patients (pts) with previously untreated metastatic Non-Small Cell Lung Cancer (NSCLC) receiving standard chemotherapy: NCIC Clinical Trials Group IND.215. NCT01783197." @default.
• W2599490334 doi "https://doi.org/10.1200/jco.2015.33.15_suppl.8046" @default.
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