Matches in SemOpenAlex for { <https://semopenalex.org/work/W2599558286> ?p ?o ?g. }
- W2599558286 endingPage "541" @default.
- W2599558286 startingPage "531" @default.
- W2599558286 abstract "Clinically, patients with significant reductions in renal function present with cardiovascular dysfunction typically termed, uremic cardiomyopathy. It is a progressive series of cardiac pathophysiological changes, including left ventricular diastolic dysfunction and hypertrophy (LVH) which sometimes progress to left ventricular dilation (LVD) and systolic dysfunction in the setting of chronic kidney disease (CKD). Uremic cardiomyopathy is almost ubiquitous in patients afflicted with end stage renal disease (ESRD). Areas covered: This article reviews recent epidemiology, pathophysiology of uremic cardiomyopathy and provide a board overview of Na/K-ATPase research with detailed discussion on the mechanisms of Na/K-ATPase/Src/ROS amplification loop. We also present clinical and preclinical evidences as well as molecular mechanism of this amplification loop in the development of uremic cardiomyopathy. A potential therapeutic peptide that targets on this loop is discussed. Expert opinion: Current clinical treatment for uremic cardiomyopathy remains disappointing. Targeting the ROS amplification loop mediated by the Na/K-ATPase signaling function may provide a novel therapeutic target for uremic cardiomyopathy and related diseases. Additional studies of Na/K-ATPase and other strategies that regulate this loop will lead to new therapeutics." @default.
- W2599558286 created "2017-04-07" @default.
- W2599558286 creator A5004658590 @default.
- W2599558286 creator A5031874278 @default.
- W2599558286 creator A5066033680 @default.
- W2599558286 creator A5077735587 @default.
- W2599558286 date "2017-04-03" @default.
- W2599558286 modified "2023-10-17" @default.
- W2599558286 title "Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy" @default.
- W2599558286 cites W1506387083 @default.
- W2599558286 cites W1506805743 @default.
- W2599558286 cites W1508102251 @default.
- W2599558286 cites W1522935251 @default.
- W2599558286 cites W1558823847 @default.
- W2599558286 cites W1563715672 @default.
- W2599558286 cites W1576990557 @default.
- W2599558286 cites W1900506567 @default.
- W2599558286 cites W1924961509 @default.
- W2599558286 cites W1934620989 @default.
- W2599558286 cites W1966158578 @default.
- W2599558286 cites W1966594228 @default.
- W2599558286 cites W1967964480 @default.
- W2599558286 cites W1968320638 @default.
- W2599558286 cites W1968567987 @default.
- W2599558286 cites W1969197079 @default.
- W2599558286 cites W1970448985 @default.
- W2599558286 cites W1972779889 @default.
- W2599558286 cites W1974140987 @default.
- W2599558286 cites W1976270302 @default.
- W2599558286 cites W1976995999 @default.
- W2599558286 cites W1977043280 @default.
- W2599558286 cites W1982706640 @default.
- W2599558286 cites W1984687894 @default.
- W2599558286 cites W1984745232 @default.
- W2599558286 cites W1987534461 @default.
- W2599558286 cites W1990964367 @default.
- W2599558286 cites W1991419403 @default.
- W2599558286 cites W1992842298 @default.
- W2599558286 cites W1994836734 @default.
- W2599558286 cites W1996510966 @default.
- W2599558286 cites W1999609273 @default.
- W2599558286 cites W2003118312 @default.
- W2599558286 cites W2006247039 @default.
- W2599558286 cites W2008187488 @default.
- W2599558286 cites W2009678908 @default.
- W2599558286 cites W2009730285 @default.
- W2599558286 cites W2009854907 @default.
- W2599558286 cites W2011928404 @default.
- W2599558286 cites W2014259599 @default.
- W2599558286 cites W2017275974 @default.
- W2599558286 cites W2024466754 @default.
- W2599558286 cites W2027046507 @default.
- W2599558286 cites W2029253559 @default.
- W2599558286 cites W2029785070 @default.
- W2599558286 cites W2032292804 @default.
- W2599558286 cites W2033792510 @default.
- W2599558286 cites W2034063092 @default.
- W2599558286 cites W2042216326 @default.
- W2599558286 cites W2043616500 @default.
- W2599558286 cites W2044041015 @default.
- W2599558286 cites W2046904899 @default.
- W2599558286 cites W2046924003 @default.
- W2599558286 cites W2047057549 @default.
- W2599558286 cites W2049414505 @default.
- W2599558286 cites W2050728158 @default.
- W2599558286 cites W2050897300 @default.
- W2599558286 cites W2051325761 @default.
- W2599558286 cites W2055224075 @default.
- W2599558286 cites W2057248497 @default.
- W2599558286 cites W2059079370 @default.
- W2599558286 cites W2059496396 @default.
- W2599558286 cites W2060896332 @default.
- W2599558286 cites W2063929316 @default.
- W2599558286 cites W2065069615 @default.
- W2599558286 cites W2068529295 @default.
- W2599558286 cites W2071045052 @default.
- W2599558286 cites W2071801132 @default.
- W2599558286 cites W2072856314 @default.
- W2599558286 cites W2076153333 @default.
- W2599558286 cites W2076710761 @default.
- W2599558286 cites W2078741316 @default.
- W2599558286 cites W2081748503 @default.
- W2599558286 cites W2081983255 @default.
- W2599558286 cites W2082602069 @default.
- W2599558286 cites W2082779145 @default.
- W2599558286 cites W2083467450 @default.
- W2599558286 cites W2085610096 @default.
- W2599558286 cites W2087945501 @default.
- W2599558286 cites W2089434962 @default.
- W2599558286 cites W2090850018 @default.
- W2599558286 cites W2092501561 @default.
- W2599558286 cites W2093166155 @default.
- W2599558286 cites W2098221350 @default.
- W2599558286 cites W2098293941 @default.
- W2599558286 cites W2099388548 @default.
- W2599558286 cites W2100039120 @default.
- W2599558286 cites W2101235425 @default.
- W2599558286 cites W2101313549 @default.