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• W2599661310 abstract "Background Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes (T2D). Apart from hyperglycemia, its pathogenesis is poorly understood. Apolipoprotein-CIII (apoC-III) associated with triglyceride metabolism, is a risk factor for cardiovascular disease. Its role in DPN is not well-established. We studied the associations of apoC-III, endothelial function and DPN. Methods In patients with T2D, anthropometric data, fasting blood, and urine were collected for biochemistry and urine albumin/creatinine measurements (uACR). Endothelial function assessments were performed by laser Doppler flowmetry/imaging. DPN was considered present if there was an abnormal finding in monofilament (≤8 of 10 points) or neurothesiometer testing ≥ 25 V on either foot. Plasma apoC-III was assessed by ELISA. Results Monofilament and neurothesiometer readings were measured in 1981 patients, mean age 57.4 ± 10.8 years old. DPN prevalence was 10.8% (n = 214). Patients with DPN compared to those without, were significantly older (p < 0.0001), with longer duration of T2D (p < 0.0001), had higher BMI (p = 0.006), higher glucose (p = 0.015) and HbA1c (p < 0.0001), Systolic blood pressure (SBP) (p < 0.0001), lower eGFR (p < 0.0001), higher urine ACR (p < 0.0001), poorer endothelium-dependent and endothelium-independent vasodilation (both p < 0.0001), higher VCAM-1 (p < 0.0001) and higher apoC-III [285.3 (195.2–405.6) vs 242.9(165.0–344.0) μg/ml]. After adjustment, log transformed apoC-III, remained independently associated with the presence of DPN (B = 0.965, SE = 0.397, p = 0.015). Conclusion Plasma apoC-III is higher in patients with DPN. Apart from its known association with lipids and macrovascular complications, this study suggests its association with DPN. Whether regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidemia and microvascular complications in T2D remains to be proven in future mechanistic and clinical studies." @default.
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• W2599661310 date "2017-07-01" @default.
• W2599661310 modified "2023-10-01" @default.
• W2599661310 title "Association of apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and peripheral neuropathy in a multi-ethnic population with type 2 diabetes" @default.
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• W2599661310 doi "https://doi.org/10.1016/j.metabol.2017.03.016" @default.
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