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- W2599688853 abstract "e21023 Background: Children with high grade gliomas (HGG) continue to have a poor prognosis despite the use of multimodality therapy. HGG may rarely occur as part of cancer predisposition syndromes (CPS) and to be associated with other primary second cancers (PSC). We aim to evaluate the incidence of PSC with HGG at King Hussein Cancer Center, Jordan Methods: We retrospectively reviewed neurooncology database between 2003 -2013. We included patients > 3 and < 18 years and in whom we could review and confirm HGG diagnosis. We described their clinical characteristics, survival and incidence of PSC Results: 42 patients were identified (29 males, 24 Jordanians). Median age was 11.3 years (3.1-17.9). Main presenting symptoms were increased intracranial pressure in 22 (52%), focal deficits in 13 and convulsions in 10. Fourteen (67%) patients with available clinical data had cafe au lait spots (CAL). Family history of cancer was reported in 13/31 and consanguinity in 10/30. Twelve patients (29%) had near total t..." @default.
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- W2599688853 date "2015-05-20" @default.
- W2599688853 modified "2023-09-27" @default.
- W2599688853 title "Incidence of second primary cancers with pediatric high grade glioma: Single institution experience." @default.
- W2599688853 doi "https://doi.org/10.1200/jco.2015.33.15_suppl.e21023" @default.
- W2599688853 hasPublicationYear "2015" @default.
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