Matches in SemOpenAlex for { <https://semopenalex.org/work/W2599688974> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2599688974 endingPage "S4" @default.
- W2599688974 startingPage "S4" @default.
- W2599688974 abstract "The left and right central nuclei of the amygdala (CeA) are homologous limbic regions capable of modulating visceral pain. Despite equivalent processing by peripheral and spinal nociceptive systems, recent data suggest that visceral pain, and specifically bladder pain, is asymmetrically processed by the left and right CeA. Data from chronic bladder pain patients shows asymmetry in functional connectivity and activation of the left and right amygdala during experimental stimulation. We sought to determine if lateralization occurs in animal models of bladder pain and furthermore, identify the cellular mechanisms of such lateralization. In our studies, we first investigated the functional contributions of the left and right CeA to bladder nociception using excitatory and inhibitory optogenetic approaches. Both light-induced activation of the right CeA and light-induced inhibition of the left CeA increased bladder pain-like responses during noxious bladder distension. These data suggest divergent pro- and anti-nociceptive functions of the right and left CeA respectively. Similar functional properties were observed during a second nociceptive measure; light-induced activation of the right CeA increased mechanical abdominal hypersensitivity in naïve mice while light-induced activation of the left CeA reversed referred pain-like measures in animals with cyclophosphamide-induced cystitis. Excitability of the left and right CeA was measured during noxious bladder distention in naïve and cyclophosphamide-sensitized animals. Evidence was found for differences in both background and evoked excitability of the two hemispheres. Current studies are evaluating the cell-type specific projections that drive these lateralized effects and responses. These data are being used to build a computational model of bladder pain processing that incorporates a pro-nociceptive drive from the right CeA and an anti-nociceptive drive from the left CeA." @default.
- W2599688974 created "2017-04-07" @default.
- W2599688974 creator A5013216738 @default.
- W2599688974 creator A5043555188 @default.
- W2599688974 creator A5050829988 @default.
- W2599688974 creator A5079651182 @default.
- W2599688974 creator A5080765013 @default.
- W2599688974 date "2017-04-01" @default.
- W2599688974 modified "2023-09-23" @default.
- W2599688974 title "(108) Asymmetric nociceptive properties of the left and right central amygdala" @default.
- W2599688974 doi "https://doi.org/10.1016/j.jpain.2017.02.014" @default.
- W2599688974 hasPublicationYear "2017" @default.
- W2599688974 type Work @default.
- W2599688974 sameAs 2599688974 @default.
- W2599688974 citedByCount "0" @default.
- W2599688974 crossrefType "journal-article" @default.
- W2599688974 hasAuthorship W2599688974A5013216738 @default.
- W2599688974 hasAuthorship W2599688974A5043555188 @default.
- W2599688974 hasAuthorship W2599688974A5050829988 @default.
- W2599688974 hasAuthorship W2599688974A5079651182 @default.
- W2599688974 hasAuthorship W2599688974A5080765013 @default.
- W2599688974 hasBestOaLocation W25996889741 @default.
- W2599688974 hasConcept C126322002 @default.
- W2599688974 hasConcept C15490471 @default.
- W2599688974 hasConcept C15744967 @default.
- W2599688974 hasConcept C169760540 @default.
- W2599688974 hasConcept C170493617 @default.
- W2599688974 hasConcept C17077164 @default.
- W2599688974 hasConcept C2779144063 @default.
- W2599688974 hasConcept C2779794527 @default.
- W2599688974 hasConcept C42219234 @default.
- W2599688974 hasConcept C548259974 @default.
- W2599688974 hasConcept C71924100 @default.
- W2599688974 hasConcept C79840881 @default.
- W2599688974 hasConceptScore W2599688974C126322002 @default.
- W2599688974 hasConceptScore W2599688974C15490471 @default.
- W2599688974 hasConceptScore W2599688974C15744967 @default.
- W2599688974 hasConceptScore W2599688974C169760540 @default.
- W2599688974 hasConceptScore W2599688974C170493617 @default.
- W2599688974 hasConceptScore W2599688974C17077164 @default.
- W2599688974 hasConceptScore W2599688974C2779144063 @default.
- W2599688974 hasConceptScore W2599688974C2779794527 @default.
- W2599688974 hasConceptScore W2599688974C42219234 @default.
- W2599688974 hasConceptScore W2599688974C548259974 @default.
- W2599688974 hasConceptScore W2599688974C71924100 @default.
- W2599688974 hasConceptScore W2599688974C79840881 @default.
- W2599688974 hasIssue "4" @default.
- W2599688974 hasLocation W25996889741 @default.
- W2599688974 hasOpenAccess W2599688974 @default.
- W2599688974 hasPrimaryLocation W25996889741 @default.
- W2599688974 hasRelatedWork W115868519 @default.
- W2599688974 hasRelatedWork W1574275693 @default.
- W2599688974 hasRelatedWork W2021683241 @default.
- W2599688974 hasRelatedWork W2081857442 @default.
- W2599688974 hasRelatedWork W2103726524 @default.
- W2599688974 hasRelatedWork W2473000443 @default.
- W2599688974 hasRelatedWork W2588619950 @default.
- W2599688974 hasRelatedWork W2893988571 @default.
- W2599688974 hasRelatedWork W2973216524 @default.
- W2599688974 hasRelatedWork W3167473131 @default.
- W2599688974 hasVolume "18" @default.
- W2599688974 isParatext "false" @default.
- W2599688974 isRetracted "false" @default.
- W2599688974 magId "2599688974" @default.
- W2599688974 workType "article" @default.