Matches in SemOpenAlex for { <https://semopenalex.org/work/W2599804978> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2599804978 abstract "9070 Background: Postcancer fatigue (PCF) is a frequently occurring problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms. We hypothesized that in fatigued patients (PCF and CFS) alterations in immune response could explain fatigue symptoms. Therefore, we examined whether the humoral and/or cellular immune response after influenza vaccination differed between fatigued patients and non-fatigued individuals and between PCF and CFS patients. Methods: PCF (n=15) and CFS patients (n=22) were vaccinated against influenza. Age and gender matched non-fatigued cancer survivors (n=12) and healthy controls (n=23) were included for comparison. Antibody responses were measured at baseline and at day 21 by a hemagglutination inhibition test. T cell responses were measured at baseline and at day 7 by a lymphocyte proliferation and activation assay. Results: Both patient groups developed seroprotection rates comparable to the accompanying control groups. Functional T cell reactivity was observed in all groups. Proliferation at baseline was significantly lower in fatigued patients compared to non-fatigued individuals. A significant increase in proliferation from baseline to day 7 was observed in fatigued patients, but not in controls. At day 7, proliferation was not significantly different between fatigued patients and non-fatigued individuals. CD4+CD127-FoxP3+ expression was significantly higher in PCF patients compared to non-fatigued cancer survivors. Conclusions: We observed a lower T cell proliferation at baseline in fatigued patients compared to non-fatigued individuals, suggesting a difference in the baseline state of the immune system between fatigued patients and non-fatigued individuals. Furthermore, the difference in CD4+CD127-FoxP3+ expression between PCF and CFS patients suggests subtle differences in immune state between these two fatigued patient groups. However, since humoral and cellular immune responses after vaccination did not differ significantly between fatigued patients and non-fatigued individuals, vaccination of fatigued patients (PCF and CFS) can be effective." @default.
- W2599804978 created "2017-04-07" @default.
- W2599804978 creator A5010049892 @default.
- W2599804978 creator A5019474260 @default.
- W2599804978 creator A5029513264 @default.
- W2599804978 creator A5043066286 @default.
- W2599804978 creator A5054086697 @default.
- W2599804978 creator A5082611542 @default.
- W2599804978 creator A5086571483 @default.
- W2599804978 creator A5087288564 @default.
- W2599804978 creator A5088638114 @default.
- W2599804978 date "2012-05-20" @default.
- W2599804978 modified "2023-09-27" @default.
- W2599804978 title "Humoral and cellular immune response after influenza vaccination in patients with postcancer fatigue and patients with chronic fatigue syndrome." @default.
- W2599804978 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.9070" @default.
- W2599804978 hasPublicationYear "2012" @default.
- W2599804978 type Work @default.
- W2599804978 sameAs 2599804978 @default.
- W2599804978 citedByCount "0" @default.
- W2599804978 crossrefType "journal-article" @default.
- W2599804978 hasAuthorship W2599804978A5010049892 @default.
- W2599804978 hasAuthorship W2599804978A5019474260 @default.
- W2599804978 hasAuthorship W2599804978A5029513264 @default.
- W2599804978 hasAuthorship W2599804978A5043066286 @default.
- W2599804978 hasAuthorship W2599804978A5054086697 @default.
- W2599804978 hasAuthorship W2599804978A5082611542 @default.
- W2599804978 hasAuthorship W2599804978A5086571483 @default.
- W2599804978 hasAuthorship W2599804978A5087288564 @default.
- W2599804978 hasAuthorship W2599804978A5088638114 @default.
- W2599804978 hasConcept C121608353 @default.
- W2599804978 hasConcept C126322002 @default.
- W2599804978 hasConcept C203014093 @default.
- W2599804978 hasConcept C22070199 @default.
- W2599804978 hasConcept C2777761686 @default.
- W2599804978 hasConcept C2778141389 @default.
- W2599804978 hasConcept C2779566273 @default.
- W2599804978 hasConcept C3017875465 @default.
- W2599804978 hasConcept C3020395016 @default.
- W2599804978 hasConcept C71924100 @default.
- W2599804978 hasConcept C8891405 @default.
- W2599804978 hasConceptScore W2599804978C121608353 @default.
- W2599804978 hasConceptScore W2599804978C126322002 @default.
- W2599804978 hasConceptScore W2599804978C203014093 @default.
- W2599804978 hasConceptScore W2599804978C22070199 @default.
- W2599804978 hasConceptScore W2599804978C2777761686 @default.
- W2599804978 hasConceptScore W2599804978C2778141389 @default.
- W2599804978 hasConceptScore W2599804978C2779566273 @default.
- W2599804978 hasConceptScore W2599804978C3017875465 @default.
- W2599804978 hasConceptScore W2599804978C3020395016 @default.
- W2599804978 hasConceptScore W2599804978C71924100 @default.
- W2599804978 hasConceptScore W2599804978C8891405 @default.
- W2599804978 hasLocation W25998049781 @default.
- W2599804978 hasOpenAccess W2599804978 @default.
- W2599804978 hasPrimaryLocation W25998049781 @default.
- W2599804978 hasRelatedWork W1409981463 @default.
- W2599804978 hasRelatedWork W1807844052 @default.
- W2599804978 hasRelatedWork W1982603177 @default.
- W2599804978 hasRelatedWork W2013417893 @default.
- W2599804978 hasRelatedWork W2026224258 @default.
- W2599804978 hasRelatedWork W2039196425 @default.
- W2599804978 hasRelatedWork W2094707721 @default.
- W2599804978 hasRelatedWork W2183595175 @default.
- W2599804978 hasRelatedWork W233093965 @default.
- W2599804978 hasRelatedWork W2400683744 @default.
- W2599804978 hasRelatedWork W2430719897 @default.
- W2599804978 hasRelatedWork W2582092178 @default.
- W2599804978 hasRelatedWork W2610471903 @default.
- W2599804978 hasRelatedWork W2612662388 @default.
- W2599804978 hasRelatedWork W2614452879 @default.
- W2599804978 hasRelatedWork W2755127506 @default.
- W2599804978 hasRelatedWork W2939500431 @default.
- W2599804978 hasRelatedWork W2993868238 @default.
- W2599804978 hasRelatedWork W2183927335 @default.
- W2599804978 hasRelatedWork W2187008078 @default.
- W2599804978 isParatext "false" @default.
- W2599804978 isRetracted "false" @default.
- W2599804978 magId "2599804978" @default.
- W2599804978 workType "article" @default.