Matches in SemOpenAlex for { <https://semopenalex.org/work/W2599847035> ?p ?o ?g. }
- W2599847035 abstract "ABSTRACT For nearly 100 years, Growth Hormone (GH) has been known to impact insulin sensitivity and risk of diabetes. However, the tissue governing the effects of GH signaling on insulin and glucose homeostasis remains unknown. Excess GH reduces fat mass and insulin sensitivity. Conversely, GH insensitivity (GHI) is associated with increased adiposity, augmented insulin sensitivity, and protection from diabetes. Here we induce adipocyte-specific GHI through conditional deletion of Jak2 (JAK2A), an obligate transducer of GH signaling. Similar to whole-body GHI, JAK2A mice had increased adiposity and extreme insulin sensitivity. Loss of adipocyte Jak2 augmented hepatic insulin sensitivity and conferred resistance to diet-induced metabolic stress without overt changes in circulating fatty acids. While GH injections induced hepatic insulin resistance in control mice, the diabetogenic action was absent in JAK2A mice. Adipocyte GH signaling directly impinged on both adipose and hepatic insulin signal transduction. Collectively, our results show that adipose tissue governs the effects of GH on insulin and glucose homeostasis. Further, we show that JAK2 mediates liver insulin sensitivity via an extra-hepatic, adipose tissue-dependent mechanism." @default.
- W2599847035 created "2017-04-07" @default.
- W2599847035 creator A5000256168 @default.
- W2599847035 creator A5002433178 @default.
- W2599847035 creator A5014359560 @default.
- W2599847035 creator A5028846143 @default.
- W2599847035 creator A5032965702 @default.
- W2599847035 creator A5042305785 @default.
- W2599847035 creator A5066392696 @default.
- W2599847035 creator A5072577601 @default.
- W2599847035 creator A5073573353 @default.
- W2599847035 creator A5079258050 @default.
- W2599847035 creator A5079590096 @default.
- W2599847035 date "2016-09-20" @default.
- W2599847035 modified "2023-09-27" @default.
- W2599847035 title "Adipocyte JAK2 Mediates Growth Hormone-Induced Hepatic Insulin Resistance" @default.
- W2599847035 cites W1556459089 @default.
- W2599847035 cites W1818618752 @default.
- W2599847035 cites W1872155217 @default.
- W2599847035 cites W1955077074 @default.
- W2599847035 cites W1964873147 @default.
- W2599847035 cites W1966586253 @default.
- W2599847035 cites W1973357670 @default.
- W2599847035 cites W1973934213 @default.
- W2599847035 cites W1975316364 @default.
- W2599847035 cites W1979510652 @default.
- W2599847035 cites W1980954879 @default.
- W2599847035 cites W1982685226 @default.
- W2599847035 cites W1984510069 @default.
- W2599847035 cites W1985775724 @default.
- W2599847035 cites W1986131332 @default.
- W2599847035 cites W1988266101 @default.
- W2599847035 cites W1989939556 @default.
- W2599847035 cites W1996154589 @default.
- W2599847035 cites W1998493448 @default.
- W2599847035 cites W2010232575 @default.
- W2599847035 cites W2012898950 @default.
- W2599847035 cites W2028347835 @default.
- W2599847035 cites W2028551167 @default.
- W2599847035 cites W2031533316 @default.
- W2599847035 cites W2040051585 @default.
- W2599847035 cites W2042056286 @default.
- W2599847035 cites W2044944092 @default.
- W2599847035 cites W2048019775 @default.
- W2599847035 cites W2048047508 @default.
- W2599847035 cites W2048170943 @default.
- W2599847035 cites W2049459543 @default.
- W2599847035 cites W2053607427 @default.
- W2599847035 cites W2062687197 @default.
- W2599847035 cites W2068382528 @default.
- W2599847035 cites W2070872244 @default.
- W2599847035 cites W2072036731 @default.
- W2599847035 cites W2074374986 @default.
- W2599847035 cites W2079264385 @default.
- W2599847035 cites W2095126334 @default.
- W2599847035 cites W2097003895 @default.
- W2599847035 cites W2097278274 @default.
- W2599847035 cites W2098690642 @default.
- W2599847035 cites W2102368078 @default.
- W2599847035 cites W2103370215 @default.
- W2599847035 cites W2105858894 @default.
- W2599847035 cites W2107958456 @default.
- W2599847035 cites W2123231186 @default.
- W2599847035 cites W2124935940 @default.
- W2599847035 cites W2135666165 @default.
- W2599847035 cites W2138077456 @default.
- W2599847035 cites W2138521217 @default.
- W2599847035 cites W2139499592 @default.
- W2599847035 cites W2146322045 @default.
- W2599847035 cites W2147781423 @default.
- W2599847035 cites W2156136676 @default.
- W2599847035 cites W2158438063 @default.
- W2599847035 cites W2162763001 @default.
- W2599847035 cites W2163321855 @default.
- W2599847035 cites W2165765668 @default.
- W2599847035 cites W2167432096 @default.
- W2599847035 cites W2169845602 @default.
- W2599847035 cites W2193344030 @default.
- W2599847035 cites W221343797 @default.
- W2599847035 cites W2335519043 @default.
- W2599847035 cites W2405221408 @default.
- W2599847035 cites W2469529327 @default.
- W2599847035 cites W2531513864 @default.
- W2599847035 cites W2589510693 @default.
- W2599847035 cites W293969398 @default.
- W2599847035 cites W3147310958 @default.
- W2599847035 cites W4242668915 @default.
- W2599847035 cites W4251924370 @default.
- W2599847035 doi "https://doi.org/10.1101/076265" @default.
- W2599847035 hasPublicationYear "2016" @default.
- W2599847035 type Work @default.
- W2599847035 sameAs 2599847035 @default.
- W2599847035 citedByCount "0" @default.
- W2599847035 crossrefType "posted-content" @default.
- W2599847035 hasAuthorship W2599847035A5000256168 @default.
- W2599847035 hasAuthorship W2599847035A5002433178 @default.
- W2599847035 hasAuthorship W2599847035A5014359560 @default.
- W2599847035 hasAuthorship W2599847035A5028846143 @default.
- W2599847035 hasAuthorship W2599847035A5032965702 @default.
- W2599847035 hasAuthorship W2599847035A5042305785 @default.