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• W2599995655 endingPage "174480691769700" @default.
• W2599995655 startingPage "174480691769700" @default.
• W2599995655 abstract "Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of inflammatory pain. It is currently not known whether FABP inhibitors exert their effects through peripheral or central mechanisms. Here, we examined FABP5 distribution in dorsal root ganglia and spinal cord and examined the analgesic effects of peripherally and centrally administered FABP5 inhibitors. Results Immunofluorescence revealed robust expression of FABP5 in lumbar dorsal root ganglia. FABP5 was distributed in peptidergic calcitonin gene-related peptide-expressing dorsal root ganglia and non-peptidergic isolectin B4-expressing dorsal root ganglia. In addition, the majority of dorsal root ganglia expressing FABP5 also expressed transient receptor potential vanilloid 1 (TRPV1) and peripherin, a marker of nociceptive fibers. Intraplantar administration of FABP5 inhibitors reduced thermal and mechanical hyperalgesia in the complete Freund's adjuvant model of chronic inflammatory pain. In contrast to its robust expression in dorsal root ganglia, FABP5 was sparsely distributed in the lumbar spinal cord and intrathecal administration of FABP inhibitor did not confer analgesic effects. Administration of FABP inhibitor via the intracerebroventricular (i.c.v.) route reduced thermal hyperalgesia. Antagonists of peroxisome proliferator-activated receptor alpha blocked the analgesic effects of peripherally and i.c.v. administered FABP inhibitor while antagonism of cannabinoid receptor 1 blocked the effects of peripheral FABP inhibition and a TRPV1 antagonist blocked the effects of i.c.v. administered inhibitor. Although FABP5 and TRPV1 were co-expressed in the periaqueductal gray region of the brain, which is known to modulate pain, knockdown of FABP5 in the periaqueductal gray using adeno-associated viruses and pharmacological FABP5 inhibition did not produce analgesic effects. Conclusions This study demonstrates that FABP5 is highly expressed in nociceptive dorsal root ganglia neurons and FABP inhibitors exert peripheral and supraspinal analgesic effects. This indicates that peripherally restricted FABP inhibitors may serve as a new class of analgesic and anti-inflammatory agents." @default.
• W2599995655 created "2017-04-07" @default.
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• W2599995655 date "2017-01-01" @default.
• W2599995655 modified "2023-09-28" @default.
• W2599995655 title "Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms" @default.
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• W2599995655 cites W1511506511 @default.
• W2599995655 cites W1539660754 @default.
• W2599995655 cites W1595517922 @default.
• W2599995655 cites W1883044208 @default.
• W2599995655 cites W1945695150 @default.
• W2599995655 cites W1962384335 @default.
• W2599995655 cites W1963486716 @default.
• W2599995655 cites W1966748794 @default.
• W2599995655 cites W1972242861 @default.
• W2599995655 cites W1976587336 @default.
• W2599995655 cites W1987120082 @default.
• W2599995655 cites W1991319303 @default.
• W2599995655 cites W1992279992 @default.
• W2599995655 cites W2001801285 @default.
• W2599995655 cites W2006216368 @default.
• W2599995655 cites W2006401652 @default.
• W2599995655 cites W2009864558 @default.
• W2599995655 cites W2013276134 @default.
• W2599995655 cites W2013744734 @default.
• W2599995655 cites W2014112647 @default.
• W2599995655 cites W2018780060 @default.
• W2599995655 cites W2021075383 @default.
• W2599995655 cites W2025059877 @default.
• W2599995655 cites W2027022038 @default.
• W2599995655 cites W2035521645 @default.
• W2599995655 cites W2036073332 @default.
• W2599995655 cites W2037850521 @default.
• W2599995655 cites W2050781058 @default.
• W2599995655 cites W2053762737 @default.
• W2599995655 cites W2055655674 @default.
• W2599995655 cites W2056402911 @default.
• W2599995655 cites W2057639794 @default.
• W2599995655 cites W2059635921 @default.
• W2599995655 cites W2063102563 @default.
• W2599995655 cites W2069731331 @default.
• W2599995655 cites W2076834233 @default.
• W2599995655 cites W2078724198 @default.
• W2599995655 cites W2079625624 @default.
• W2599995655 cites W2082493917 @default.
• W2599995655 cites W2082903312 @default.
• W2599995655 cites W2089073273 @default.
• W2599995655 cites W2094241280 @default.
• W2599995655 cites W2094469214 @default.
• W2599995655 cites W2102984876 @default.
• W2599995655 cites W2108879539 @default.
• W2599995655 cites W2119756897 @default.
• W2599995655 cites W2119872155 @default.
• W2599995655 cites W2120857280 @default.
• W2599995655 cites W2130435998 @default.
• W2599995655 cites W2134742719 @default.
• W2599995655 cites W2140338667 @default.
• W2599995655 cites W2143684129 @default.
• W2599995655 cites W2158037744 @default.
• W2599995655 cites W2160761602 @default.
• W2599995655 cites W2165128851 @default.
• W2599995655 cites W2271388481 @default.
• W2599995655 cites W2335677672 @default.
• W2599995655 cites W898188430 @default.
• W2599995655 doi "https://doi.org/10.1177/1744806917697007" @default.
• W2599995655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5407663" @default.
• W2599995655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28326944" @default.
• W2599995655 hasPublicationYear "2017" @default.
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