Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600057763> ?p ?o ?g. }
- W2600057763 endingPage "e1310358" @default.
- W2600057763 startingPage "e1310358" @default.
- W2600057763 abstract "Up to now, the efficacy of programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) blockade in pancreatic cancer (PC) remains uncertain. Serum levels of soluble PD-1 and PD-L1 (sPD-1/sPD-L1) have been reported to be independent prognostic factors in solid tumors susceptible to checkpoint blockade. Provenience, regulation and immunologic function of sPD-1 and sPD-L1 in cancer are poorly understood. To the best of our knowledge, sPD-1 and sPD-L1 have not been measured conjointly in any cancer type yet. In contrast to other tumor entities, sPD-1/sPD-L1 levels did not indicate an adverse outcome in a cohort of 41 patients with advanced PC. We observed a close positive correlation of sPD-L1 levels with sPD-1 in patients with advanced PC, suggesting a common provenience and regulation of sPD-1 and sPD-L1 in cancer patients. Higher sPD-L1 levels were present in patients with elevated C-reactive protein or strong tumoral T cell infiltration, while no correlation of sPD-L1 levels with tumoral PD-L1 expression was found. Our findings indicate that sPD-1 and sPD-L1 are markers of systemic inflammation in (pancreatic) cancer. In a subset of PC patients, elevation in sPD-L1 levels might be caused by an inflammatory tumor type - independent of tumoral PD-L1 expression." @default.
- W2600057763 created "2017-04-07" @default.
- W2600057763 creator A5011137037 @default.
- W2600057763 creator A5022323779 @default.
- W2600057763 creator A5029807838 @default.
- W2600057763 creator A5031266401 @default.
- W2600057763 creator A5037754184 @default.
- W2600057763 creator A5042147282 @default.
- W2600057763 creator A5045048264 @default.
- W2600057763 creator A5053960245 @default.
- W2600057763 creator A5055766851 @default.
- W2600057763 creator A5077502588 @default.
- W2600057763 creator A5089260058 @default.
- W2600057763 date "2017-05-04" @default.
- W2600057763 modified "2023-10-14" @default.
- W2600057763 title "Serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death ligand 1 (sPD-L1) in advanced pancreatic cancer" @default.
- W2600057763 cites W1133776218 @default.
- W2600057763 cites W1945743078 @default.
- W2600057763 cites W1965999622 @default.
- W2600057763 cites W1970415573 @default.
- W2600057763 cites W2023355189 @default.
- W2600057763 cites W2044363258 @default.
- W2600057763 cites W2049078823 @default.
- W2600057763 cites W2054373401 @default.
- W2600057763 cites W2066230562 @default.
- W2600057763 cites W2073125824 @default.
- W2600057763 cites W2098746033 @default.
- W2600057763 cites W2100519108 @default.
- W2600057763 cites W2101653483 @default.
- W2600057763 cites W2101670384 @default.
- W2600057763 cites W2107002473 @default.
- W2600057763 cites W2111895881 @default.
- W2600057763 cites W2121963549 @default.
- W2600057763 cites W2124427232 @default.
- W2600057763 cites W2145758395 @default.
- W2600057763 cites W2151253787 @default.
- W2600057763 cites W2161558877 @default.
- W2600057763 cites W2165480504 @default.
- W2600057763 cites W2170552969 @default.
- W2600057763 cites W2171475863 @default.
- W2600057763 cites W2267145540 @default.
- W2600057763 cites W2298948109 @default.
- W2600057763 cites W2324094374 @default.
- W2600057763 cites W2345568581 @default.
- W2600057763 cites W2409503508 @default.
- W2600057763 cites W2469831351 @default.
- W2600057763 cites W2470779635 @default.
- W2600057763 cites W2498914772 @default.
- W2600057763 cites W2546935275 @default.
- W2600057763 cites W2550947038 @default.
- W2600057763 cites W2561235181 @default.
- W2600057763 cites W2564351475 @default.
- W2600057763 cites W2580601893 @default.
- W2600057763 cites W2582362986 @default.
- W2600057763 cites W4210976084 @default.
- W2600057763 doi "https://doi.org/10.1080/2162402x.2017.1310358" @default.
- W2600057763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5467983" @default.
- W2600057763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28638732" @default.
- W2600057763 hasPublicationYear "2017" @default.
- W2600057763 type Work @default.
- W2600057763 sameAs 2600057763 @default.
- W2600057763 citedByCount "102" @default.
- W2600057763 countsByYear W26000577632018 @default.
- W2600057763 countsByYear W26000577632019 @default.
- W2600057763 countsByYear W26000577632020 @default.
- W2600057763 countsByYear W26000577632021 @default.
- W2600057763 countsByYear W26000577632022 @default.
- W2600057763 countsByYear W26000577632023 @default.
- W2600057763 crossrefType "journal-article" @default.
- W2600057763 hasAuthorship W2600057763A5011137037 @default.
- W2600057763 hasAuthorship W2600057763A5022323779 @default.
- W2600057763 hasAuthorship W2600057763A5029807838 @default.
- W2600057763 hasAuthorship W2600057763A5031266401 @default.
- W2600057763 hasAuthorship W2600057763A5037754184 @default.
- W2600057763 hasAuthorship W2600057763A5042147282 @default.
- W2600057763 hasAuthorship W2600057763A5045048264 @default.
- W2600057763 hasAuthorship W2600057763A5053960245 @default.
- W2600057763 hasAuthorship W2600057763A5055766851 @default.
- W2600057763 hasAuthorship W2600057763A5077502588 @default.
- W2600057763 hasAuthorship W2600057763A5089260058 @default.
- W2600057763 hasBestOaLocation W26000577631 @default.
- W2600057763 hasConcept C116569031 @default.
- W2600057763 hasConcept C121608353 @default.
- W2600057763 hasConcept C126322002 @default.
- W2600057763 hasConcept C169382597 @default.
- W2600057763 hasConcept C170493617 @default.
- W2600057763 hasConcept C185592680 @default.
- W2600057763 hasConcept C190283241 @default.
- W2600057763 hasConcept C2777701055 @default.
- W2600057763 hasConcept C2780210213 @default.
- W2600057763 hasConcept C2781053074 @default.
- W2600057763 hasConcept C31573885 @default.
- W2600057763 hasConcept C502942594 @default.
- W2600057763 hasConcept C55493867 @default.
- W2600057763 hasConcept C71924100 @default.
- W2600057763 hasConceptScore W2600057763C116569031 @default.
- W2600057763 hasConceptScore W2600057763C121608353 @default.
- W2600057763 hasConceptScore W2600057763C126322002 @default.