FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600111712> ?p ?o ?g. }

• W2600111712 endingPage "80" @default.
• W2600111712 startingPage "76" @default.
• W2600111712 abstract "Monthly specimens collected from FEM-PrEP—a Phase III trial [1] were investigated for the detection of acute HIV (AHI) infection. To evaluate the efficiency of the study-specific HIV algorithm in detecting AHI, and the performance of each of the serological and molecular tests used in diagnosing new infections, and their contribution to narrowing the window period. A total of 83 pre-seroconversion specimens from 61 seroconverters from the FEM-PrEP trial were further analyzed in a sub-study. During the trial, HIV seroconversion was diagnosed on site using a testing algorithm with simple/rapid tests (SRTs) and confirmed with a gold standard testing algorithm (see short communication: Fig. 1). The infection date was determined more accurately by the use of standard ELISAs and Nucleic Acid Amplification Tests (NAAT) in a look-back procedure. For this sub-study, the international central laboratory repeated the study algorithm using SRTs. A total of 83 pre-seroconversions specimens from 61 seroconverters were analyzed in a look-back procedure. RNA was detected in 35/61 seroconverters at the visit before the seroconversion visit as determined at the study sites. Four seroconversion dates were inaccurate at one study site as the international central laboratory detected the HIV infection one visit earlier using the same test algorithm. Using the gold standard, an additional seroconversion was detected at an earlier visit. The combined antigen/antibody and the single antigen test had a higher sensitivity compared to the SRTs in detecting acute infections. In the FEM-PrEP trial, the international central laboratory detected a small number of seroconversions one month earlier than the study sites using the same study algorithm. Standard tests are still the most sensitive tests in detecting pre-seroconversion or acute HIV infection, but they are costly, time consuming and not recommended for use on-site in a clinical trial." @default.
• W2600111712 created "2017-04-07" @default.
• W2600111712 creator A5009941538 @default.
• W2600111712 creator A5027900172 @default.
• W2600111712 creator A5048284744 @default.
• W2600111712 creator A5060910203 @default.
• W2600111712 creator A5063810881 @default.
• W2600111712 creator A5067774407 @default.
• W2600111712 creator A5071372315 @default.
• W2600111712 creator A5076916827 @default.
• W2600111712 creator A5078037028 @default.
• W2600111712 creator A5082839296 @default.
• W2600111712 date "2017-08-01" @default.
• W2600111712 modified "2023-10-03" @default.
• W2600111712 title "Detection of new HIV infections in a multicentre HIV antiretroviral pre-exposure prophylaxis trial" @default.
• W2600111712 cites W1970906662 @default.
• W2600111712 cites W1981847755 @default.
• W2600111712 cites W1991419465 @default.
• W2600111712 cites W1993882803 @default.
• W2600111712 cites W2005013388 @default.
• W2600111712 cites W2019764023 @default.
• W2600111712 cites W2126141460 @default.
• W2600111712 cites W2148157725 @default.
• W2600111712 cites W2159667783 @default.
• W2600111712 cites W2161290118 @default.
• W2600111712 cites W2165861955 @default.
• W2600111712 cites W2168251450 @default.
• W2600111712 cites W2334368177 @default.
• W2600111712 doi "https://doi.org/10.1016/j.jcv.2017.03.013" @default.
• W2600111712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28351689" @default.
• W2600111712 hasPublicationYear "2017" @default.
• W2600111712 type Work @default.
• W2600111712 sameAs 2600111712 @default.
• W2600111712 citedByCount "3" @default.
• W2600111712 countsByYear W26001117122018 @default.
• W2600111712 countsByYear W26001117122019 @default.
• W2600111712 countsByYear W26001117122020 @default.
• W2600111712 crossrefType "journal-article" @default.
• W2600111712 hasAuthorship W2600111712A5009941538 @default.
• W2600111712 hasAuthorship W2600111712A5027900172 @default.
• W2600111712 hasAuthorship W2600111712A5048284744 @default.
• W2600111712 hasAuthorship W2600111712A5060910203 @default.
• W2600111712 hasAuthorship W2600111712A5063810881 @default.
• W2600111712 hasAuthorship W2600111712A5067774407 @default.
• W2600111712 hasAuthorship W2600111712A5071372315 @default.
• W2600111712 hasAuthorship W2600111712A5076916827 @default.
• W2600111712 hasAuthorship W2600111712A5078037028 @default.
• W2600111712 hasAuthorship W2600111712A5082839296 @default.
• W2600111712 hasConcept C126322002 @default.
• W2600111712 hasConcept C159047783 @default.
• W2600111712 hasConcept C159654299 @default.
• W2600111712 hasConcept C203014093 @default.
• W2600111712 hasConcept C2777451964 @default.
• W2600111712 hasConcept C2777594644 @default.
• W2600111712 hasConcept C3013748606 @default.
• W2600111712 hasConcept C40993552 @default.
• W2600111712 hasConcept C45189115 @default.
• W2600111712 hasConcept C71924100 @default.
• W2600111712 hasConceptScore W2600111712C126322002 @default.
• W2600111712 hasConceptScore W2600111712C159047783 @default.
• W2600111712 hasConceptScore W2600111712C159654299 @default.
• W2600111712 hasConceptScore W2600111712C203014093 @default.
• W2600111712 hasConceptScore W2600111712C2777451964 @default.
• W2600111712 hasConceptScore W2600111712C2777594644 @default.
• W2600111712 hasConceptScore W2600111712C3013748606 @default.
• W2600111712 hasConceptScore W2600111712C40993552 @default.
• W2600111712 hasConceptScore W2600111712C45189115 @default.
• W2600111712 hasConceptScore W2600111712C71924100 @default.
• W2600111712 hasLocation W26001117121 @default.
• W2600111712 hasLocation W26001117122 @default.
• W2600111712 hasOpenAccess W2600111712 @default.
• W2600111712 hasPrimaryLocation W26001117121 @default.
• W2600111712 hasRelatedWork W2044715 @default.
• W2600111712 hasRelatedWork W2068650174 @default.
• W2600111712 hasRelatedWork W2075546204 @default.
• W2600111712 hasRelatedWork W2341821976 @default.
• W2600111712 hasRelatedWork W2352108061 @default.
• W2600111712 hasRelatedWork W3025281866 @default.
• W2600111712 hasRelatedWork W3110097208 @default.
• W2600111712 hasRelatedWork W3128830683 @default.
• W2600111712 hasRelatedWork W4246573306 @default.
• W2600111712 hasRelatedWork W4256415444 @default.
• W2600111712 hasVolume "93" @default.
• W2600111712 isParatext "false" @default.
• W2600111712 isRetracted "false" @default.
• W2600111712 magId "2600111712" @default.
• W2600111712 workType "article" @default.