FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600168059> ?p ?o ?g. }

• W2600168059 abstract "Myelin-containing macrophages and microglia are the most abundant immune cells in active multiple sclerosis (MS) lesions. Our recent transcriptomic analysis demonstrated that collectin placenta 1 (CL-P1) is one of the most potently induced genes in macrophages after uptake of myelin. CL-P1 is a type II transmembrane protein with both a collagen-like and carbohydrate recognition domain, which plays a key role in host defense. In this study we sought to determine the dynamics of CL-P1 expression on myelin-containing phagocytes and define the role that it plays in MS lesion development. We show that myelin uptake increases the cell surface expression of CL-P1 by mouse and human macrophages, but not by primary mouse microglia in vitro. In active demyelinating MS lesions, CL-P1 immunoreactivity was localized to perivascular and parenchymal myelin-laden phagocytes. Finally, we demonstrate that CL-P1 is involved in myelin internalization as knockdown of CL-P1 markedly reduced myelin uptake. Collectively, our data indicate that CL-P1 is a novel receptor involved in myelin uptake by phagocytes and likely plays a role in MS lesion development." @default.
• W2600168059 created "2017-04-07" @default.
• W2600168059 creator A5005940112 @default.
• W2600168059 creator A5009613217 @default.
• W2600168059 creator A5032207000 @default.
• W2600168059 creator A5034419719 @default.
• W2600168059 creator A5041367864 @default.
• W2600168059 creator A5051450048 @default.
• W2600168059 creator A5070890845 @default.
• W2600168059 creator A5074042132 @default.
• W2600168059 creator A5081302685 @default.
• W2600168059 creator A5083747549 @default.
• W2600168059 creator A5077641792 @default.
• W2600168059 date "2017-03-20" @default.
• W2600168059 modified "2023-09-23" @default.
• W2600168059 title "Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes" @default.
• W2600168059 cites W1540808432 @default.
• W2600168059 cites W1577577364 @default.
• W2600168059 cites W1585651720 @default.
• W2600168059 cites W1952053031 @default.
• W2600168059 cites W1966584984 @default.
• W2600168059 cites W1968272594 @default.
• W2600168059 cites W1971094792 @default.
• W2600168059 cites W1976621212 @default.
• W2600168059 cites W1977956402 @default.
• W2600168059 cites W1984029930 @default.
• W2600168059 cites W1987515900 @default.
• W2600168059 cites W1988822418 @default.
• W2600168059 cites W1992180550 @default.
• W2600168059 cites W1994360619 @default.
• W2600168059 cites W1997522187 @default.
• W2600168059 cites W1999952543 @default.
• W2600168059 cites W2008863207 @default.
• W2600168059 cites W2010824741 @default.
• W2600168059 cites W2024140382 @default.
• W2600168059 cites W2032039569 @default.
• W2600168059 cites W2038251898 @default.
• W2600168059 cites W2038484123 @default.
• W2600168059 cites W2046280963 @default.
• W2600168059 cites W2051508093 @default.
• W2600168059 cites W2057247682 @default.
• W2600168059 cites W2058539998 @default.
• W2600168059 cites W2060437747 @default.
• W2600168059 cites W2063133273 @default.
• W2600168059 cites W2069067531 @default.
• W2600168059 cites W2071292091 @default.
• W2600168059 cites W2076865759 @default.
• W2600168059 cites W2081607618 @default.
• W2600168059 cites W2083331927 @default.
• W2600168059 cites W2090777067 @default.
• W2600168059 cites W2090890529 @default.
• W2600168059 cites W2094044389 @default.
• W2600168059 cites W2100864926 @default.
• W2600168059 cites W2124617804 @default.
• W2600168059 cites W2132924600 @default.
• W2600168059 cites W2143507280 @default.
• W2600168059 cites W2146733472 @default.
• W2600168059 cites W2149039469 @default.
• W2600168059 cites W2159443316 @default.
• W2600168059 cites W2169252930 @default.
• W2600168059 cites W918300749 @default.
• W2600168059 doi "https://doi.org/10.1038/srep44794" @default.
• W2600168059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5357964" @default.
• W2600168059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28317919" @default.
• W2600168059 hasPublicationYear "2017" @default.
• W2600168059 type Work @default.
• W2600168059 sameAs 2600168059 @default.
• W2600168059 citedByCount "29" @default.
• W2600168059 countsByYear W26001680592017 @default.
• W2600168059 countsByYear W26001680592018 @default.
• W2600168059 countsByYear W26001680592019 @default.
• W2600168059 countsByYear W26001680592020 @default.
• W2600168059 countsByYear W26001680592021 @default.
• W2600168059 countsByYear W26001680592022 @default.
• W2600168059 countsByYear W26001680592023 @default.
• W2600168059 crossrefType "journal-article" @default.
• W2600168059 hasAuthorship W2600168059A5005940112 @default.
• W2600168059 hasAuthorship W2600168059A5009613217 @default.
• W2600168059 hasAuthorship W2600168059A5032207000 @default.
• W2600168059 hasAuthorship W2600168059A5034419719 @default.
• W2600168059 hasAuthorship W2600168059A5041367864 @default.
• W2600168059 hasAuthorship W2600168059A5051450048 @default.
• W2600168059 hasAuthorship W2600168059A5070890845 @default.
• W2600168059 hasAuthorship W2600168059A5074042132 @default.
• W2600168059 hasAuthorship W2600168059A5077641792 @default.
• W2600168059 hasAuthorship W2600168059A5081302685 @default.
• W2600168059 hasAuthorship W2600168059A5083747549 @default.
• W2600168059 hasBestOaLocation W26001680591 @default.
• W2600168059 hasConcept C133493029 @default.
• W2600168059 hasConcept C136449434 @default.
• W2600168059 hasConcept C139770010 @default.
• W2600168059 hasConcept C169760540 @default.
• W2600168059 hasConcept C170493617 @default.
• W2600168059 hasConcept C185592680 @default.
• W2600168059 hasConcept C203014093 @default.
• W2600168059 hasConcept C2776914184 @default.
• W2600168059 hasConcept C2778163477 @default.
• W2600168059 hasConcept C2778609137 @default.
• W2600168059 hasConcept C2779830541 @default.
• W2600168059 hasConcept C2780072125 @default.

• next