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- W2600174552 abstract "Introduction: The objectives of this study were evaluate hepatitis B virus (HBV) serological markers in children and adolescents followed up at the Child Institute of the Hospital das Clinicas, Faculdade de Medicina de Sao Paulo, Universidade de Sao Paulo; identify chronic HBV carriers and susceptible individuals in the intrafamilial environment; characterize HBV genotypes; and identify mutations in the patients and household contacts. Methods: Ninetyfive hepatitis B surface antigen-positive children aged <19 years and 118 household contacts were enrolled in this study. Commercial kits were used for the detection of serological markers, and PCR was used for genotyping. Results: Hepatitis B e antigen (HBeAg) was detected in 66.3% (63/95) of cases. Three of the 30 HBeAg-negative and anti-HBeAg-positive patients presented with precore mutations and 11 presented with mutations in the basal core promoter (BCP). Genotype A was identified in 39 (43.8%) patients, genotype D in 45 (50.6%), and genotype C in 5 (5.6%). Of the 118 relatives, 40 were chronic HBV carriers, 52 presented with the anti-HBc marker, 19 were vaccinated, and 7 were susceptible. Among the relatives, genotypes A, D, and C were the most frequent. One parent presented with a precore mutation and 4 presented with BCP mutations. Conclusions: Genotypes A and D were the most frequent among children, adolescents, and their relatives. The high prevalence of HBV in the families showed the possibility of its intrafamilial transmission." @default.
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- W2600174552 date "2012-01-01" @default.
- W2600174552 modified "2023-09-27" @default.
- W2600174552 title "Hepatitis B virus infection in children, adolescents, and their relatives: genotype distribution and precore and core gene mutations Infecção pelo vírus da hepatite B em crianças, adolescentes e seus familiares: distribuição dos genótipos e mutações no gene pré-core e core" @default.
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