Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600178581> ?p ?o ?g. }
- W2600178581 abstract "Neuropathic pain is a complex chronic condition characterized by various sensory, cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are also afflicted with depression and anxiety disorders, a pattern that is also seen in animal models. Furthermore, clinical and preclinical studies indicate that chronic pain corresponds with adaptations in several brain networks involved in mood, motivation, and reward. Chronic stress is also a major risk factor for depression. We investigated whether chronic pain and stress affect similar molecular mechanisms and whether chronic pain can affect gene expression patterns that are involved in depression. Using two mouse models of neuropathic pain and depression [spared nerve injury (SNI) and chronic unpredictable stress (CUS)], we performed next-generation RNA sequencing and pathway analysis to monitor changes in gene expression in the nucleus accumbens (NAc), the medial prefrontal cortex (mPFC), and the periaqueductal gray (PAG). In addition to finding unique transcriptome profiles across these regions, we identified a substantial number of signaling pathway-associated genes with similar changes in expression in both SNI and CUS mice. Many of these genes have been implicated in depression, anxiety, and chronic pain in patients. Our study provides a resource of the changes in gene expression induced by long-term neuropathic pain in three distinct brain regions and reveals molecular connections between pain and chronic stress." @default.
- W2600178581 created "2017-04-07" @default.
- W2600178581 creator A5002111854 @default.
- W2600178581 creator A5008134007 @default.
- W2600178581 creator A5020197301 @default.
- W2600178581 creator A5030323647 @default.
- W2600178581 creator A5044436902 @default.
- W2600178581 creator A5078821560 @default.
- W2600178581 creator A5082381091 @default.
- W2600178581 creator A5090962514 @default.
- W2600178581 date "2017-03-21" @default.
- W2600178581 modified "2023-10-06" @default.
- W2600178581 title "Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression" @default.
- W2600178581 cites W108332423 @default.
- W2600178581 cites W1521659744 @default.
- W2600178581 cites W1578507364 @default.
- W2600178581 cites W1599631170 @default.
- W2600178581 cites W1675980378 @default.
- W2600178581 cites W1697553032 @default.
- W2600178581 cites W1710764867 @default.
- W2600178581 cites W1790440433 @default.
- W2600178581 cites W1871144505 @default.
- W2600178581 cites W1928871450 @default.
- W2600178581 cites W1964228449 @default.
- W2600178581 cites W1965066118 @default.
- W2600178581 cites W1966351672 @default.
- W2600178581 cites W1968260526 @default.
- W2600178581 cites W1968562278 @default.
- W2600178581 cites W1969557387 @default.
- W2600178581 cites W1969628982 @default.
- W2600178581 cites W1971166407 @default.
- W2600178581 cites W1973271844 @default.
- W2600178581 cites W1973816589 @default.
- W2600178581 cites W1974057366 @default.
- W2600178581 cites W1975954553 @default.
- W2600178581 cites W1977430165 @default.
- W2600178581 cites W1978420707 @default.
- W2600178581 cites W1979687697 @default.
- W2600178581 cites W1982050226 @default.
- W2600178581 cites W1983578249 @default.
- W2600178581 cites W1984280194 @default.
- W2600178581 cites W1985598247 @default.
- W2600178581 cites W1986097552 @default.
- W2600178581 cites W1987253310 @default.
- W2600178581 cites W1989830384 @default.
- W2600178581 cites W1990891103 @default.
- W2600178581 cites W1990957877 @default.
- W2600178581 cites W1990970865 @default.
- W2600178581 cites W1993606937 @default.
- W2600178581 cites W1993769517 @default.
- W2600178581 cites W1996815356 @default.
- W2600178581 cites W1998026463 @default.
- W2600178581 cites W1998807228 @default.
- W2600178581 cites W199967300 @default.
- W2600178581 cites W2001572109 @default.
- W2600178581 cites W2002044194 @default.
- W2600178581 cites W2002620715 @default.
- W2600178581 cites W2003164705 @default.
- W2600178581 cites W2003949705 @default.
- W2600178581 cites W2007113486 @default.
- W2600178581 cites W2010084449 @default.
- W2600178581 cites W2010370084 @default.
- W2600178581 cites W2018831144 @default.
- W2600178581 cites W2020348231 @default.
- W2600178581 cites W2021253208 @default.
- W2600178581 cites W2022082745 @default.
- W2600178581 cites W2022673879 @default.
- W2600178581 cites W2023995612 @default.
- W2600178581 cites W2027440324 @default.
- W2600178581 cites W2028152254 @default.
- W2600178581 cites W2028679671 @default.
- W2600178581 cites W2030487055 @default.
- W2600178581 cites W2031094958 @default.
- W2600178581 cites W2032359153 @default.
- W2600178581 cites W2035421865 @default.
- W2600178581 cites W2037214999 @default.
- W2600178581 cites W2038378894 @default.
- W2600178581 cites W2038487059 @default.
- W2600178581 cites W2038905876 @default.
- W2600178581 cites W2043038606 @default.
- W2600178581 cites W2047491025 @default.
- W2600178581 cites W2048646811 @default.
- W2600178581 cites W2049101564 @default.
- W2600178581 cites W2049704911 @default.
- W2600178581 cites W2049938995 @default.
- W2600178581 cites W2050836998 @default.
- W2600178581 cites W2051508016 @default.
- W2600178581 cites W2053202141 @default.
- W2600178581 cites W2053544091 @default.
- W2600178581 cites W2053619173 @default.
- W2600178581 cites W2054275187 @default.
- W2600178581 cites W2055193356 @default.
- W2600178581 cites W2056001419 @default.
- W2600178581 cites W2056565769 @default.
- W2600178581 cites W2058219079 @default.
- W2600178581 cites W2060035717 @default.
- W2600178581 cites W2060969944 @default.
- W2600178581 cites W2061940479 @default.
- W2600178581 cites W2064080816 @default.
- W2600178581 cites W2064776460 @default.